Ethyl 2-(2-chlorophenyl)-5-(4-(methoxycarbonyl)-2-methylphenyl)-1H-indole-1-carboxylate

Base Information

Chemical Name:Ethyl 2-(2-chlorophenyl)-5-(4-(methoxycarbonyl)-2-methylphenyl)-1H-indole-1-carboxylate
CAS No.:1279107-83-3
Molecular Formula:C₂₆H₂₂ClNO₄
Molecular Weight:447.918
Hs Code.:

Synonyms:Ethyl 2-(2-chlorophenyl)-5-(4-(methoxycarbonyl)-2-methylphenyl)-1H-indole-1-carboxylate

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Chemical Property of Ethyl 2-(2-chlorophenyl)-5-(4-(methoxycarbonyl)-2-methylphenyl)-1H-indole-1-carboxylate

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Technology Process of Ethyl 2-(2-chlorophenyl)-5-(4-(methoxycarbonyl)-2-methylphenyl)-1H-indole-1-carboxylate

There total 7 articles about Ethyl 2-(2-chlorophenyl)-5-(4-(methoxycarbonyl)-2-methylphenyl)-1H-indole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 1279106-97-6
ethyl 2-(2-chlorophenyl)-5-iodo-1H-indole-1-carboxylate

: 473596-87-1
4-methoxycarbonyl-2-methylbenzeneboronic acid pinacol ester

: 1279107-83-3
Ethyl 2-(2-chlorophenyl)-5-(4-(methoxycarbonyl)-2-methylphenyl)-1H-indole-1-carboxylate

Guidance literature:: With potassium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; at 20 - 60 ℃;

Reference yield:

: 59-48-3
2-oxoindole

: 1279107-83-3
Ethyl 2-(2-chlorophenyl)-5-(4-(methoxycarbonyl)-2-methylphenyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1: N-iodo-succinimide; acetic acid / water / 1.5 h

2: triethylamine / tetrahydrofuran / 1 h / 20 °C

3: ammonium carbonate / N,N-dimethyl-formamide / 3.33 h / 0 - 15 °C

4: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

5: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 20 - 60 °C / Inert atmosphere

6: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 20 - 60 °C

With N-iodo-succinimide; ammonium carbonate; sodium hydrogencarbonate; potassium carbonate; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 193354-13-1
5-iodo-1,3-dihydro-indol-2-one

: 1279107-83-3
Ethyl 2-(2-chlorophenyl)-5-(4-(methoxycarbonyl)-2-methylphenyl)-1H-indole-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / tetrahydrofuran / 1 h / 20 °C

2: ammonium carbonate / N,N-dimethyl-formamide / 3.33 h / 0 - 15 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

4: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethanol; toluene / 20 - 60 °C / Inert atmosphere

5: potassium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 20 - 60 °C

With ammonium carbonate; sodium hydrogencarbonate; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;