(E)-1-(2-Hydroxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine

Base Information

Chemical Name:(E)-1-(2-Hydroxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine
CAS No.:114312-26-4
Molecular Formula:C₂₇H₂₈N₂O₂
Molecular Weight:412.532
Hs Code.:

(E)-1-(2-Hydroxy-6,11-dihydrodibenz<b,e>oxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine

Synonyms:(E)-1-(2-Hydroxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine

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Chemical Property of (E)-1-(2-Hydroxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine

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Technology Process of (E)-1-(2-Hydroxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine

There total 9 articles about (E)-1-(2-Hydroxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 114312-46-8,139305-53-6
(E)-1-(2-tert-Butyldimethylsilyloxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine dimaleate

: 114312-26-4
(E)-1-(2-Hydroxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 0.5h; Ambient temperature;
DOI:10.1248/cpb.39.2564

Reference yield:

: 87-41-2
2-benzofuran-1(3H)-one

: 114312-26-4
(E)-1-(2-Hydroxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine

Guidance literature:: Multi-step reaction with 8 steps

1: 1 h / 200 °C

2: 89 percent / (CF₃CO)2O, BF₃*Et₂O / CH₂Cl₂ / 1 h / Ambient temperature

3: 71 percent / pyridine*HCl / 2 h / 180 °C

4: 90 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

5: NaBH₄ / methanol / 0.33 h / 0 °C

6: SOCl₂ / 0.17 h / Ambient temperature

7: 87 percent / CH₂Cl₂ / 1 h / Ambient temperature

8: 69 percent / Bu₄NF / tetrahydrofuran / 0.5 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; thionyl chloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; pyridine hydrochloride; trifluoroacetic anhydride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2564

Reference yield:

: 23560-67-0
2-methoxy-6,11-dihydrodibenz[b,e]oxepin-11-one

: 114312-26-4
(E)-1-(2-Hydroxy-6,11-dihydrodibenzoxepin-11-yl)-4-(3-phenyl-2-propenyl)piperazine

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / pyridine*HCl / 2 h / 180 °C

2: 90 percent / imidazole / dimethylformamide / 1 h / Ambient temperature

3: NaBH₄ / methanol / 0.33 h / 0 °C

4: SOCl₂ / 0.17 h / Ambient temperature

5: 87 percent / CH₂Cl₂ / 1 h / Ambient temperature

6: 69 percent / Bu₄NF / tetrahydrofuran / 0.5 h / Ambient temperature

With 1H-imidazole; sodium tetrahydroborate; thionyl chloride; tetrabutyl ammonium fluoride; pyridine hydrochloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.39.2564