2-benzyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

Base Information

Chemical Name:2-benzyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride
CAS No.:1109229-97-1
Molecular Formula:C₃₇H₃₄F₅N₃O₃*ClH
Molecular Weight:700.148
Hs Code.:

2-benzyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

Synonyms:2-benzyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

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Chemical Property of 2-benzyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

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Technology Process of 2-benzyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

There total 7 articles about 2-benzyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1109229-92-6
2-benzyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide

: 1109229-97-1
2-benzyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; ethyl acetate; at 0 ℃; for 0.25h;

Reference yield:

: 1109229-95-9
2-benzyl-5-bromo-3,4-dihydroisoquinolin-1(2H)-one

: 1109229-97-1
2-benzyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1: water; potassium acetate; potassium iodide / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 26 h / 100 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

3: hydrogenchloride / diethyl ether; ethyl acetate / 0.25 h / 0 °C

With hydrogenchloride; water; potassium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium iodide; palladium diacetate; triphenylphosphine; In diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1109229-94-8
methyl benzyl[2-(2-bromophenyl)ethyl]carbamate

: 1109229-97-1
2-benzyl-N-[(1S,2R)-1-(3,5-difluorobenzyl)-2-hydroxy-3-({1-[3-(trifluoromethyl)phenyl]cyclopropyl}amino)propyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-5-carboxamide hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1: dmap; trifluoromethylsulfonic anhydride / dichloromethane / 0 - 20 °C / Inert atmosphere

2: water; potassium acetate; potassium iodide / palladium diacetate; triphenylphosphine / N,N-dimethyl-formamide / 26 h / 100 °C

3: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 20 h / 20 °C

4: hydrogenchloride / diethyl ether; ethyl acetate / 0.25 h / 0 °C

With hydrogenchloride; dmap; trifluoromethylsulfonic anhydride; water; potassium acetate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; potassium iodide; palladium diacetate; triphenylphosphine; In diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;