(R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-N-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-d][1,4]diazepin-3-yl)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

Base Information

Chemical Name:(R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-N-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-d][1,4]diazepin-3-yl)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide
CAS No.:1274806-10-8
Molecular Formula:C₂₅H₃₂F₃N₇O₄S₃
Molecular Weight:647.767
Hs Code.:

(R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-N-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-d][1,4]diazepin-3-yl)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

Synonyms:(R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-N-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-d][1,4]diazepin-3-yl)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

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Chemical Property of (R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-N-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-d][1,4]diazepin-3-yl)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

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Technology Process of (R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-N-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-d][1,4]diazepin-3-yl)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

There total 3 articles about (R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-N-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-d][1,4]diazepin-3-yl)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1421687-45-7
(R)-tert-butyl 3-(4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-3-((trifluoromethyl)sulfonyl)phenylsulfonamido)-8,9-dihydro-5H-[1,2,4]triazolo[4,3-d][1,4]diazepine-7(6H)-carboxylate

: 1274806-10-8
(R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-N-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-d][1,4]diazepin-3-yl)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; for 2h; Inert atmosphere;
DOI:10.1021/ml300321d

Reference yield:

: 1274804-51-1
4,5,7,8-tetrahydro-1,2,3a,6-tetraaza-azulene-6-carboxylic acid tert-butyl ester

: 1274806-10-8
(R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-N-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-d][1,4]diazepin-3-yl)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide; bromine / water / 16 h / 20 °C / pH 12 / Inert atmosphere

2: caesium carbonate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / toluene / 16 h / 90 °C / Inert atmosphere

3: trifluoroacetic acid / dichloromethane / 2 h / Inert atmosphere

With copper(l) iodide; bromine; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; caesium carbonate; trifluoroacetic acid; sodium hydroxide; In dichloromethane; water; toluene;
DOI:10.1021/ml300321d

Reference yield:

: 1251020-06-0
tert-butyl 3-bromo-8,9-dihydro-5H-[1,2,4]triazolo[4,3-d][1,4]diazepine-7(6H)-carboxylate

: 1274806-10-8
(R)-4-((4-(dimethylamino)-1-(phenylthio)butan-2-yl)amino)-N-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-d][1,4]diazepin-3-yl)-3-((trifluoromethyl)sulfonyl)benzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; copper(l) iodide / toluene / 16 h / 90 °C / Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h / Inert atmosphere

With copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; caesium carbonate; trifluoroacetic acid; In dichloromethane; toluene;
DOI:10.1021/ml300321d