methyl 4-{2-[2-[3-(benzylthio)propyl]-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

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Chemical Name:methyl 4-{2-[2-[3-(benzylthio)propyl]-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate
CAS No.:934285-36-6
Molecular Formula:C₄₁H₃₈ClNO₃S
Molecular Weight:660.277
Hs Code.:

Synonyms:methyl 4-{2-[2-[3-(benzylthio)propyl]-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

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Chemical Property of methyl 4-{2-[2-[3-(benzylthio)propyl]-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

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Technology Process of methyl 4-{2-[2-[3-(benzylthio)propyl]-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

There total 8 articles about methyl 4-{2-[2-[3-(benzylthio)propyl]-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 540524-75-2
methyl 4-{2-[2-(3-bromopropyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

: 100-53-8
phenylmethanethiol

: 934285-36-6
methyl 4-{2-[2-[3-(benzylthio)propyl]-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

Guidance literature:: phenylmethanethiol; With sodium hydride; In N,N-dimethyl-formamide; for 0.5h;

methyl 4-{2-[2-(3-bromopropyl)-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate; In N,N-dimethyl-formamide; for 1h; Further stages.;
DOI:10.1021/jm061131z

Reference yield:

: 479422-24-7
methyl 4-[2-[5-chloro-(1-diphenylmethyl)-2-methyl-1H-indol-3-yl]ethoxy]benzoate

: 934285-36-6
methyl 4-{2-[2-[3-(benzylthio)propyl]-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

Guidance literature:: Multi-step reaction with 8 steps

1.1: NBS; benzoyl peroxide / CCl₄ / 2.5 h / Heating

2.1: 0.750 g / Ag₂CO₃; H₂O / acetone

3.1: 91 percent / tetrahydrofuran / 1 h

4.1: 97 percent / morpholine / Pd(PPh₃)4 / tetrahydrofuran / 4 h

5.1: 79 percent / H₂ / Pt/C / methanol / 24 h / 760.05 Torr

6.1: (COCl)2 / CH₂Cl₂ / 1 h

6.2: 83 percent / Zn(BH₄)2; TMEDA / diethyl ether / 0.25 h

7.1: 86 percent / CBr₄; PS-PPh₃ / CH₂Cl₂ / 2 h

8.1: NaH / dimethylformamide / 0.5 h

8.2: 57 percent / dimethylformamide / 1 h

With morpholine; N-Bromosuccinimide; oxalyl dichloride; PS-PPh₃; carbon tetrabromide; water; hydrogen; sodium hydride; silver carbonate; dibenzoyl peroxide; platinum on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; tetrachloromethane; dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm061131z

Reference yield:

: 934285-29-7
methyl 4-{2-[2-[(1E)-3-(allyloxy)-3-oxoprop-1-en-1-yl]-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

: 934285-36-6
methyl 4-{2-[2-[3-(benzylthio)propyl]-5-chloro-1-(diphenylmethyl)-1H-indol-3-yl]ethoxy}benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 97 percent / morpholine / Pd(PPh₃)4 / tetrahydrofuran / 4 h

2.1: 79 percent / H₂ / Pt/C / methanol / 24 h / 760.05 Torr

3.1: (COCl)2 / CH₂Cl₂ / 1 h

3.2: 83 percent / Zn(BH₄)2; TMEDA / diethyl ether / 0.25 h

4.1: 86 percent / CBr₄; PS-PPh₃ / CH₂Cl₂ / 2 h

5.1: NaH / dimethylformamide / 0.5 h

5.2: 57 percent / dimethylformamide / 1 h

With morpholine; oxalyl dichloride; PS-PPh₃; carbon tetrabromide; hydrogen; sodium hydride; platinum on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm061131z