Technology Process of (E)-6-(3,5-dimethoxystyryl)-5,6-dihydro-2H-pyran-2-one
There total 11 articles about (E)-6-(3,5-dimethoxystyryl)-5,6-dihydro-2H-pyran-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
Grubbs catalyst first generation;
In
dichloromethane;
for 8h;
Reflux;
DOI:10.1016/j.bmc.2012.03.059
- Guidance literature:
-
With
tert.-butylhydroperoxide; dipyridinium dichromate;
In
dichloromethane;
at -40 ℃;
for 2h;
Inert atmosphere;
DOI:10.1007/s12272-013-0099-1
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium hydride / tetrahydrofuran; N,N-dimethyl-formamide; mineral oil / 0.25 h / 0 °C / Inert atmosphere
1.2: 0 - 20 °C / Inert atmosphere
2.1: diisobutylaluminium hydride / dichloromethane / 0.5 h / -78 °C / Inert atmosphere
2.2: 0 °C / Inert atmosphere
3.1: 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione / ethyl acetate / 3.5 h / 80 °C / Air atmosphere
4.1: tetrahydrofuran; diethyl ether / 0.5 h / -78 °C / Inert atmosphere
4.2: -78 °C / Inert atmosphere
5.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C / Inert atmosphere
6.1: Grubbs catalyst first generation / dichloromethane / 8 h / Reflux
With
Grubbs catalyst first generation; sodium hydride; diisobutylaluminium hydride; triethylamine; 1-hydroxy-3H-benz[d][1,2]iodoxole-1,3-dione;
In
tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; mineral oil;
1.1: Horner-Wadsworth-Emmons olefination / 1.2: Horner-Wadsworth-Emmons olefination;
DOI:10.1016/j.bmc.2012.03.059
