N-(4-chloro-2-((2S)-2-(5-chloro-7-(3-cyanopiperazin-1-yl)pyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

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Chemical Name:N-(4-chloro-2-((2S)-2-(5-chloro-7-(3-cyanopiperazin-1-yl)pyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide
CAS No.:1470032-62-2
Molecular Formula:C₂₄H₂₆Cl₂N₈O₃S
Molecular Weight:577.494
Hs Code.:

Synonyms:N-(4-chloro-2-((2S)-2-(5-chloro-7-(3-cyanopiperazin-1-yl)pyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

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Chemical Property of N-(4-chloro-2-((2S)-2-(5-chloro-7-(3-cyanopiperazin-1-yl)pyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

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Technology Process of N-(4-chloro-2-((2S)-2-(5-chloro-7-(3-cyanopiperazin-1-yl)pyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

There total 10 articles about N-(4-chloro-2-((2S)-2-(5-chloro-7-(3-cyanopiperazin-1-yl)pyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.0%

: piperazine-2-carbonitrile bishydrochloride

: 1353628-61-1
(S)-N-(4-chloro-2-(2-(5,7-dichloropyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

: 1470032-62-2
N-(4-chloro-2-((2S)-2-(5-chloro-7-(3-cyanopiperazin-1-yl)pyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; at 20 ℃;

Reference yield:

: 26250-84-0
(S)-(-)-1-(tert-butoxycarbonyl)-2-piperidinecarboxylic acid

: 1470032-62-2
N-(4-chloro-2-((2S)-2-(5-chloro-7-(3-cyanopiperazin-1-yl)pyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 4 h

2.1: sodium hexamethyldisilazane / tetrahydrofuran; hexane / 0.33 h / -78 - -40 °C

2.2: 2 h / -78 - -40 °C

3.1: hydrazinium monoacetate / ethanol / 16 h / 20 °C

4.1: sodium methylate / methanol / 5 h / 78 °C

5.1: trichlorophosphate / 3 h / 100 °C

6.1: triethylamine / dichloromethane / 0.67 h / 20 °C / Cooling with ice

7.1: sodium hydrogencarbonate / tetrahydrofuran / 20 °C

With sodium methylate; sodium hexamethyldisilazane; hydrazinium monoacetate; sodium hydrogencarbonate; caesium carbonate; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 203056-27-3
tert-butyl (2S)-2-{[methoxy(methyl)amino]-carbonyl}piperidine-1-carboxylate

: 1470032-62-2
N-(4-chloro-2-((2S)-2-(5-chloro-7-(3-cyanopiperazin-1-yl)pyrazolo[1,5-a]pyrimidin-2-yl)piperidine-1-carbonyl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.42 h / -78 - -20 °C / Inert atmosphere

1.2: 3 h / -78 - -45 °C

2.1: hydrazinium monoacetate / ethanol / 16 h / 20 °C

3.1: sodium methylate / methanol / 5 h / 78 °C

4.1: trichlorophosphate / 3 h / 100 °C

5.1: triethylamine / dichloromethane / 0.67 h / 20 °C / Cooling with ice

6.1: sodium hydrogencarbonate / tetrahydrofuran / 20 °C

With sodium methylate; sodium hexamethyldisilazane; hydrazinium monoacetate; sodium hydrogencarbonate; triethylamine; trichlorophosphate; In tetrahydrofuran; methanol; ethanol; dichloromethane;