4-hydroxy-7-chloro-5-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

Base Information

Chemical Name:4-hydroxy-7-chloro-5-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran
CAS No.:120034-21-1
Molecular Formula:C₂₀H₂₂ClNO₃
Molecular Weight:359.853
Hs Code.:

Synonyms:4-hydroxy-7-chloro-5-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

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Chemical Property of 4-hydroxy-7-chloro-5-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

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Technology Process of 4-hydroxy-7-chloro-5-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

There total 5 articles about 4-hydroxy-7-chloro-5-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 33797-51-2
eschenmoser's salt

: 120034-16-4
4-hydroxy-7-chloro-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

: 120034-21-1
4-hydroxy-7-chloro-5-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

Guidance literature:: In dichloromethane; for 20h; Ambient temperature;
DOI:10.1021/jm00126a008

Reference yield:

: 120034-10-8
3-chloro-5-tert-butyl-2,6-dihydroxyacetophenone

: 120034-21-1
4-hydroxy-7-chloro-5-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

Guidance literature:: Multi-step reaction with 4 steps

2: 81 percent / ZnI₂, NaCNBH₄ / 1,2-dichloro-ethane / 6 h / Heating

3: 58 percent / AlCl₃ / CH₂Cl₂; various solvent(s) / 1 h / 0 °C

4: 80 percent / CH₂Cl₂ / 20 h / Ambient temperature

With aluminium trichloride; sodium cyanoborohydride; zinc(II) iodide; In dichloromethane; 1,2-dichloro-ethane;
DOI:10.1021/jm00126a008

Reference yield:

: 120034-13-1
4-hydroxy-7-chloro-5-tert-butyl-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

: 120034-21-1
4-hydroxy-7-chloro-5-<(dimethylamino)methyl>-2-<(4'-methoxyphenyl)methyl>-3-methylbenzofuran

Guidance literature:: Multi-step reaction with 2 steps

1: 58 percent / AlCl₃ / CH₂Cl₂; various solvent(s) / 1 h / 0 °C

2: 80 percent / CH₂Cl₂ / 20 h / Ambient temperature

With aluminium trichloride; In dichloromethane;
DOI:10.1021/jm00126a008