isonoraptazepine

Base Information

• Chemical Name: isonoraptazepine
• CAS No.: 122485-01-2
• Molecular Formula: C15H17 N3
• Molecular Weight: 239.31558
• Mol file: 122485-01-2.mol

Synonyms:isonoraptazepine

Chemical Property of isonoraptazepine

Chemical Property:

• Vapor Pressure: 4.86E-07mmHg at 25°C
• Boiling Point: 413.3°Cat760mmHg
• Flash Point: 203.7°C
• PSA: 20.20000
• Density: 1.28g/cm³
• LogP: 2.20390

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of isonoraptazepine

There total 8 articles about isonoraptazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

3b,4,6,7-tetrahydro-4,7-dioxo-5H,9H-pyrazino<2,1-c>pyrrolo<1,2-a><1,4>benzodiazepine (122485-08-9) → 3b,4,6,7-tetrahydro-5H,9H-pyrazino<2,1-c>pyrrolo<1,2-a><1,4>benzodiazepine (122485-01-2)

Guidance literature:

With lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran; at 0 - 5 ℃; for 2h;

DOI:10.1016/S0040-4020(01)80106-X

Reference yield: 80.0%

3b,4,6,7-tetrahydro-7-oxo-5H,9H-pyrazino<2,1-c>pyrrolo<1,2-a><1,4>benzodiazepine (122485-03-4) → 3b,4,6,7-tetrahydro-5H,9H-pyrazino<2,1-c>pyrrolo<1,2-a><1,4>benzodiazepine (122485-01-2)

Guidance literature:

With lithium aluminium tetrahydride; sulfuric acid; In tetrahydrofuran; at 0 - 5 ℃; for 2h;

DOI:10.1016/S0040-4020(01)80106-X

Reference yield:

5,6-dihydro-4-ethoxycarbonyl-4H-pyrrolo<1,2-a><1,4>benzodiazepine (122485-06-7) → 3b,4,6,7-tetrahydro-5H,9H-pyrazino<2,1-c>pyrrolo<1,2-a><1,4>benzodiazepine (122485-01-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / CH₂Cl₂ / 1.) 0-5 deg C, 1 h; 2.) r.t., 4 h

2: 50 percent / H₂ / 10percent Pd/C / ethanol / 6 h / 50 °C / 3040 Torr

3: 89 percent / lithium aluminum hydride, 100percent sulfuric acid / tetrahydrofuran / 2 h / 0 - 5 °C

With lithium aluminium tetrahydride; sulfuric acid; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; palladium on activated charcoal; In tetrahydrofuran; ethanol; dichloromethane;

DOI:10.1016/S0040-4020(01)80106-X

upstream raw materials:

3b,4,6,7-tetrahydro-7-oxo-5H,9H-pyrazino<2,1-c>pyrrolo<1,2-a><1,4>benzodiazepine

3b,4,6,7-tetrahydro-4,7-dioxo-5H,9H-pyrazino<2,1-c>pyrrolo<1,2-a><1,4>benzodiazepine

2-(1-pyrrolyl)benzylamine

5,6-dihydro-4-ethoxycarbonyl-4H-pyrrolo<1,2-a><1,4>benzodiazepine

Downstream raw materials:

(4-Chloro-phenyl)-(9,10,12,12a-tetrahydro-8H-3a,8a,11-triaza-dibenzo[e,h]azulen-11-yl)-methanone

3b,4,6,7-tetrahydro-5-methyl-5H,9H-pyrazino<2,1-c>pyrrolo<1,2-a><1,4>benzodiazepine