Amiloride

Base Information

• Chemical Name: Amiloride
• CAS No.: 2609-46-3
• Molecular Formula: C6H8ClN7O
• Molecular Weight: 229.629
• Hs Code.: 2934999090
• European Community (EC) Number: 220-024-7
• UNII: 7DZO8EB0Z3
• DSSTox Substance ID: DTXSID9043853
• Nikkaji Number: J9.514A
• Wikipedia: Amiloride
• Wikidata: Q419995
• NCI Thesaurus Code: C61633
• RXCUI: 644
• Pharos Ligand ID: 1DKCKQ65KQGJ
• ChEMBL ID: CHEMBL945
• Mol file: 2609-46-3.mol

Synonyms:Amidal;Amiduret Trom;Amiloberag;Amiloride;Amiloride Hydrochloride;Amiloride Hydrochloride, Anhydrous;Anhydrous Amiloride Hydrochloride;Hydrochloride, Amiloride;Hydrochloride, Anhydrous Amiloride;Kaluril;Midamor;Midoride;Modamide;Trom, Amiduret

Chemical Property of Amiloride

Chemical Property:

• Vapor Pressure: 1.08E-15mmHg at 25°C
• Melting Point: 240.5-241.5°
• Refractive Index: 1.884
• Boiling Point: 628.1 °C at 760 mmHg
• PKA: pKa 8.7 (Uncertain)
• Flash Point: 333.7 °C
• PSA: 156.79000
• Density: 2.11 g/cm³
• LogP: 1.27100
• Water Solubility.: 659g/L(25 oC)
• XLogP3: -0.7
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 1
• Exact Mass: 229.0478856
• Heavy Atom Count: 15
• Complexity: 279

Purity/Quality:

99.9% ^*data from raw suppliers

Amiloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Drug Classes: Diuretics
• Canonical SMILES: C1(=C(N=C(C(=N1)Cl)N)N)C(=O)N=C(N)N
• Recent ClinicalTrials: Evaluating Alternative Medical Therapies in Primary Hyperparathyroidism
• Recent EU Clinical Trials: Treatment of vascular stiffness in patients with autosomal dominant polycystic kidney disease
• Description: Amyloride is also a potassium sparing diuretic that exhibits moderate activity. It is not an antagonist of aldosterone. It inhibits reabsorption of sodium ions and reduces excretion of potassium ions.
• Uses: Diuretic. Amyloride is rarely used individually—as a rule it is used in combination with thiazides or loop diuretics. It is mainly used in combination with thiazide diuretics for cardiac insufficiency and hypertension, especially in cases where it is necessary to prevent hypokalemia. Amiloride is an epithelial sodium channel blocker.
• Therapeutic Function: Diuretic
• Clinical Use: Amiloride, another potassium-sparing diuretic, is an aminopyrazine structurally related to triamterene as an open-chain analogue. Similar to triamterene, it interferes with the process of cationic exchange in the distal convoluted tubule by blocking luminal sodium channels. It blocks the reabsorption of sodium ion and the secretion of potassium ion. It has no effect on the action of aldosterone. Oral amiloride is approximately 50% absorbed, with a duration of action of 10 to 12 hours, which is slightly longer than that for triamterene. Although triamterene is extensively metabolized, approximately 50% of amiloride is excreted unchanged. Renal impairment can increase its elimination half-life. Like triamterene, amiloride combined with a thiazide or loop diuretic is used to treat edema or hypertension.