(3R,5S,7R,9S,10R,12R)-3,10-Dimethyl-12,13-isopropylidenedioxy-7,9-(4-methoxybenzylidenedioxy)-5-methoxymethoxytridecane-2,8-dione

Base Information

Chemical Name:(3R,5S,7R,9S,10R,12R)-3,10-Dimethyl-12,13-isopropylidenedioxy-7,9-(4-methoxybenzylidenedioxy)-5-methoxymethoxytridecane-2,8-dione
CAS No.:201012-09-1
Molecular Formula:C₂₈H₄₂O₉
Molecular Weight:522.636
Hs Code.:

Synonyms:(3R,5S,7R,9S,10R,12R)-3,10-Dimethyl-12,13-isopropylidenedioxy-7,9-(4-methoxybenzylidenedioxy)-5-methoxymethoxytridecane-2,8-dione

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Chemical Property of (3R,5S,7R,9S,10R,12R)-3,10-Dimethyl-12,13-isopropylidenedioxy-7,9-(4-methoxybenzylidenedioxy)-5-methoxymethoxytridecane-2,8-dione

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Technology Process of (3R,5S,7R,9S,10R,12R)-3,10-Dimethyl-12,13-isopropylidenedioxy-7,9-(4-methoxybenzylidenedioxy)-5-methoxymethoxytridecane-2,8-dione

There total 19 articles about (3R,5S,7R,9S,10R,12R)-3,10-Dimethyl-12,13-isopropylidenedioxy-7,9-(4-methoxybenzylidenedioxy)-5-methoxymethoxytridecane-2,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 201012-06-8
(2S,3R,5S,7R,8R,9S,10R,12R)-3,10-Dimethyl-12,13-isopropylidenedioxy-7,9-(4-methoxybenzylidenedioxy)-5-methoxymethoxytridecane-2,8-diol

: 201012-09-1
(3R,5S,7R,9S,10R,12R)-3,10-Dimethyl-12,13-isopropylidenedioxy-7,9-(4-methoxybenzylidenedioxy)-5-methoxymethoxytridecane-2,8-dione

Guidance literature:: With tetrapropylammonium perruthennate; 4 A molecular sieve; 4-methylmorpholine N-oxide; In dichloromethane; for 3h; Ambient temperature; 1.) r.t., 10 min, 2.) r.t., 3 h;

Reference yield:

: 101470-81-9
(2R,3S)-1-Benzyloxymethyloxy-2-methylbutan-3-ol

: 201012-09-1
(3R,5S,7R,9S,10R,12R)-3,10-Dimethyl-12,13-isopropylidenedioxy-7,9-(4-methoxybenzylidenedioxy)-5-methoxymethoxytridecane-2,8-dione

Guidance literature:: Multi-step reaction with 7 steps

1: 96 percent / i-Pr₂NEt / CH₂Cl₂ / 0.67 h / Ambient temperature

2: 84.9 percent / H₂ / 50percent Raney Ni / ethanol / 120 h / Ambient temperature

3: 78.1 percent / Ph₃P, imidazole, I₂ / benzene / 0.33 h / Ambient temperature

4: 38 percent / t-BuLi / diethyl ether; pentane / 1.) -78 deg C, 10 min; r.t., 1 h, 2.) r.t., 11 h

5: 86 percent / i-Pr₂NEt / CH₂Cl₂ / 17 h / Ambient temperature

6: 35 percent / TBAF, 4 Angstroem molecular sieves / hexamethylphosphoric acid triamide / 15 h / 80 °C

7: 72 percent / 4-methylmorpholine N-oxide, 4 Angstroem molecular sieves, tetrapropylammonium perruthenate / CH₂Cl₂ / 3 h / Ambient temperature; 1.) r.t., 10 min, 2.) r.t., 3 h

With 1H-imidazole; tetrapropylammonium perruthennate; 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; iodine; tert.-butyl lithium; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; nickel; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; dichloromethane; pentane; benzene;

Reference yield:

: 201011-94-1
[2-((1S,2R)-3-Benzyloxymethoxy-1,2-dimethyl-propoxymethoxy)-ethyl]-trimethyl-silane

: 201012-09-1
(3R,5S,7R,9S,10R,12R)-3,10-Dimethyl-12,13-isopropylidenedioxy-7,9-(4-methoxybenzylidenedioxy)-5-methoxymethoxytridecane-2,8-dione

Guidance literature:: Multi-step reaction with 6 steps

1: 84.9 percent / H₂ / 50percent Raney Ni / ethanol / 120 h / Ambient temperature

2: 78.1 percent / Ph₃P, imidazole, I₂ / benzene / 0.33 h / Ambient temperature

3: 38 percent / t-BuLi / diethyl ether; pentane / 1.) -78 deg C, 10 min; r.t., 1 h, 2.) r.t., 11 h

4: 86 percent / i-Pr₂NEt / CH₂Cl₂ / 17 h / Ambient temperature

5: 35 percent / TBAF, 4 Angstroem molecular sieves / hexamethylphosphoric acid triamide / 15 h / 80 °C

6: 72 percent / 4-methylmorpholine N-oxide, 4 Angstroem molecular sieves, tetrapropylammonium perruthenate / CH₂Cl₂ / 3 h / Ambient temperature; 1.) r.t., 10 min, 2.) r.t., 3 h

With 1H-imidazole; tetrapropylammonium perruthennate; 4 A molecular sieve; tetrabutyl ammonium fluoride; hydrogen; iodine; tert.-butyl lithium; 4-methylmorpholine N-oxide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; nickel; In N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether; ethanol; dichloromethane; pentane; benzene;