5-{allyloxycarbonylmethyl-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-4-tert-butoxycarbonylamino-pentanoic acid benzyl ester

Base Information

Chemical Name:5-{allyloxycarbonylmethyl-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-4-tert-butoxycarbonylamino-pentanoic acid benzyl ester
CAS No.:931396-35-9
Molecular Formula:C₂₉H₃₈N₄O₉
Molecular Weight:586.642
Hs Code.:

5-{allyloxycarbonylmethyl-[(5-methyl-2,4-dioxo-3,4-dihydro-2<i>H</i>-pyrimidin-1-yl)-acetyl]-amino}-4-<i>tert</i>-butoxycarbonylamino-pentanoic acid benzyl ester

Synonyms:5-{allyloxycarbonylmethyl-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-4-tert-butoxycarbonylamino-pentanoic acid benzyl ester

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Chemical Property of 5-{allyloxycarbonylmethyl-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-4-tert-butoxycarbonylamino-pentanoic acid benzyl ester

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Technology Process of 5-{allyloxycarbonylmethyl-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-4-tert-butoxycarbonylamino-pentanoic acid benzyl ester

There total 12 articles about 5-{allyloxycarbonylmethyl-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-4-tert-butoxycarbonylamino-pentanoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: C₂₄H₃₃BrN₂O₇

: 65-71-4,28806-14-6,691841-57-3
thymin

: 931396-35-9
5-{allyloxycarbonylmethyl-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-4-tert-butoxycarbonylamino-pentanoic acid benzyl ester

Guidance literature:: With potassium carbonate; regioselective reaction;
DOI:10.1016/j.mencom.2015.01.017

Reference yield: 55.0%

: 931396-33-7
5-(allyloxycarbonylmethyl-amino)-4-tert-butoxycarbonylamino-pentanoic acid benzyl ester

: 20924-05-4
thymidyl acetic acid

: 931396-35-9
5-{allyloxycarbonylmethyl-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-4-tert-butoxycarbonylamino-pentanoic acid benzyl ester

Guidance literature:: With 4-methyl-morpholine; triethylamine; isobutyl chloroformate; In N,N-dimethyl-formamide; at -20 ℃;
DOI:10.1134/S0012500806050016

Reference yield:

: 868837-28-9
allyl 2-(2-nitrophenylsulfonamido)acetate

: 931396-35-9
5-{allyloxycarbonylmethyl-[(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-acetyl]-amino}-4-tert-butoxycarbonylamino-pentanoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DEAD; PPh₃ / tetrahydrofuran

2: 65 percent / PhSH; K₂CO₃ / acetonitrile

3: 55 percent / N-isobutyl chloroformate; N-methylmorpholine; triethylamine / dimethylformamide / -20 °C

With 4-methyl-morpholine; potassium carbonate; thiophenol; triethylamine; triphenylphosphine; diethylazodicarboxylate; isobutyl chloroformate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 1: Mitsunobu condensation;
DOI:10.1134/S0012500806050016