6,7-methylenedioxyquinoline-4-carboxylic acid N-[2-(morpholin-4-yl)ethyl]-N-(2-iodo-4,5-dimethoxyphenyl)amide

Base Information

Chemical Name:6,7-methylenedioxyquinoline-4-carboxylic acid N-[2-(morpholin-4-yl)ethyl]-N-(2-iodo-4,5-dimethoxyphenyl)amide
CAS No.:884850-50-4
Molecular Formula:C₂₅H₂₆IN₃O₆
Molecular Weight:591.402
Hs Code.:

Synonyms:6,7-methylenedioxyquinoline-4-carboxylic acid N-[2-(morpholin-4-yl)ethyl]-N-(2-iodo-4,5-dimethoxyphenyl)amide

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Chemical Property of 6,7-methylenedioxyquinoline-4-carboxylic acid N-[2-(morpholin-4-yl)ethyl]-N-(2-iodo-4,5-dimethoxyphenyl)amide

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Technology Process of 6,7-methylenedioxyquinoline-4-carboxylic acid N-[2-(morpholin-4-yl)ethyl]-N-(2-iodo-4,5-dimethoxyphenyl)amide

There total 9 articles about 6,7-methylenedioxyquinoline-4-carboxylic acid N-[2-(morpholin-4-yl)ethyl]-N-(2-iodo-4,5-dimethoxyphenyl)amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 3647-69-6
4-(2-chloroethyl)morpholine hydrochride

: 550372-56-0
6,7-methylenedioxyquinoline-4-carboxylic acid N-(2-iodo-4,5-dimethoxyphenyl)amide

: 884850-50-4
6,7-methylenedioxyquinoline-4-carboxylic acid N-[2-(morpholin-4-yl)ethyl]-N-(2-iodo-4,5-dimethoxyphenyl)amide

Guidance literature:: With sodium hydride; sodium iodide; In N,N-dimethyl-formamide; at 60 ℃; for 6h;
DOI:10.1016/j.bmc.2005.12.028

Reference yield:

: 881-70-9
3',4'-dimethoxyacetanilide

: 884850-50-4
6,7-methylenedioxyquinoline-4-carboxylic acid N-[2-(morpholin-4-yl)ethyl]-N-(2-iodo-4,5-dimethoxyphenyl)amide

Guidance literature:: Multi-step reaction with 4 steps

1: 52 percent / iodine monochloride; acetic acid / CH₂Cl₂

2: 93 percent / NaOH / ethanol; H₂O / 4 h / Heating

3: 512 mg / triethylamine / CH₂Cl₂ / Heating

4: 81 percent / sodium hydride; sodium iodide / dimethylformamide; various solvent(s) / 6 h / 60 °C

With sodium hydroxide; Iodine monochloride; sodium hydride; acetic acid; triethylamine; sodium iodide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.12.028

Reference yield:

: 14268-66-7
benzo[1,3]dioxolo-5-ylamine

: 884850-50-4
6,7-methylenedioxyquinoline-4-carboxylic acid N-[2-(morpholin-4-yl)ethyl]-N-(2-iodo-4,5-dimethoxyphenyl)amide

Guidance literature:: Multi-step reaction with 6 steps

1: 44 percent / iron(III) chloride; acetic acid / 1.5 h / Heating

2: 65 percent / SeO₂ / dioxane; H₂O / 4.5 h / Heating

3: 90 percent / potassium permanganate; pyridine / H₂O / -5 - 20 °C

4: thionyl chloride / 2 h / Heating

5: 512 mg / triethylamine / CH₂Cl₂ / Heating

6: 81 percent / sodium hydride; sodium iodide / dimethylformamide; various solvent(s) / 6 h / 60 °C

With pyridine; potassium permanganate; selenium(IV) oxide; thionyl chloride; iron(III) chloride; sodium hydride; acetic acid; triethylamine; sodium iodide; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.12.028