tert-butyl {2-[[(3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-1-yl)carbonyl](methyl)amino]ethyl}carbamate

Base Information

Chemical Name:tert-butyl {2-[[(3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-1-yl)carbonyl](methyl)amino]ethyl}carbamate
CAS No.:1034474-46-8
Molecular Formula:C₂₉H₂₇Cl₂N₉O₄
Molecular Weight:636.497
Hs Code.:

tert-butyl {2-[[(3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-1-yl)carbonyl](methyl)amino]ethyl}carbamate

Synonyms:tert-butyl {2-[[(3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-1-yl)carbonyl](methyl)amino]ethyl}carbamate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of tert-butyl {2-[[(3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-1-yl)carbonyl](methyl)amino]ethyl}carbamate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of tert-butyl {2-[[(3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-1-yl)carbonyl](methyl)amino]ethyl}carbamate

There total 16 articles about tert-butyl {2-[[(3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-1-yl)carbonyl](methyl)amino]ethyl}carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 202207-79-2
tert-butyl (2-(methylamino)ethyl)carbamate hydrochloride

: 32315-10-9
bis(trichloromethyl) carbonate

: 1034474-21-9
3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-1,2,3-benzotriazol-4-yl]oxy}benzonitrile

: 1034474-46-8
tert-butyl {2-[[(3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-1-yl)carbonyl](methyl)amino]ethyl}carbamate

Guidance literature:: bis(trichloromethyl) carbonate; 3-chloro-5-{[5-chloro-1-(1H-pyrazolo[3,4-b]pyridin-3-ylmethyl)-1H-1,2,3-benzotriazol-4-yl]oxy}benzonitrile; With pyridine; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃;

tert-butyl (2-(methylamino)ethyl)carbamate hydrochloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 0.166667h;

Reference yield:

: 1034474-44-6
4-(3-bromo-5-chlorophenoxy)-5-chloro-1H-benzotriazole

: 1034474-46-8
tert-butyl {2-[[(3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-1-yl)carbonyl](methyl)amino]ethyl}carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2.5 h / 90 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

3.1: trifluoroacetic acid / 0.08 h / 20 °C

4.1: pyridine; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

4.2: 0.17 h / 0 - 20 °C

With pyridine; caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1034474-41-3
2-(3-bromo-5-chlorophenoxy)-1-chloro-3-nitrobenzene

: 1034474-46-8
tert-butyl {2-[[(3-{[5-chloro-4-(3-chloro-5-cyanophenoxy)-1H-1,2,3-benzotriazol-1-yl]methyl}-1H-pyrazolo[3,4-b]pyridin-1-yl)carbonyl](methyl)amino]ethyl}carbamate

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium tert-butylate; N,N,N-trimethylhydrazinium iodide; copper(l) chloride / N,N-dimethyl-formamide / 0.25 h / -40 - 0 °C

2.1: tin(ll) chloride / methanol / 10 h / 75 °C

3.1: acetic acid; sodium nitrite / water / 1.5 h / 15 °C

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2.5 h / 90 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 20 °C

6.1: trifluoroacetic acid / 0.08 h / 20 °C

7.1: pyridine; N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

7.2: 0.17 h / 0 - 20 °C

With pyridine; potassium tert-butylate; N,N,N-trimethylhydrazinium iodide; caesium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; copper(l) chloride; tin(ll) chloride; sodium nitrite; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In methanol; dichloromethane; water; N,N-dimethyl-formamide;