4-[(10S)-dihydroartemisinin-10-oxy]benzaldehyde N₄-(2,5-dimethylphenyl)thiosemicarbazone

Base Information

• Chemical Name: 4-[(10S)-dihydroartemisinin-10-oxy]benzaldehyde N₄-(2,5-dimethylphenyl)thiosemicarbazone
• CAS No.: 1309469-87-1
• Molecular Formula: C₃₁H₃₉N₃O₅S
• Molecular Weight: 565.734

Synonyms:4-[(10S)-dihydroartemisinin-10-oxy]benzaldehyde N₄-(2,5-dimethylphenyl)thiosemicarbazone

Chemical Property of 4-[(10S)-dihydroartemisinin-10-oxy]benzaldehyde N₄-(2,5-dimethylphenyl)thiosemicarbazone

Chemical Property:

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Technology Process of 4-[(10S)-dihydroartemisinin-10-oxy]benzaldehyde N₄-(2,5-dimethylphenyl)thiosemicarbazone

There total 6 articles about 4-[(10S)-dihydroartemisinin-10-oxy]benzaldehyde N₄-(2,5-dimethylphenyl)thiosemicarbazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

(10S)-10-(4-formylphenyl)dihydroartemisinin (1287216-57-2) + 4-(2',5'-Dimethylphenyl)-thiosemicarbazid (64374-53-4) → 4-[(10S)-dihydroartemisinin-10-oxy]benzaldehyde N4-(2,5-dimethylphenyl)thiosemicarbazone (1309469-87-1)

Guidance literature:

With acetic acid; In ethanol; at 20 ℃; for 2h;

DOI:10.3390/molecules16064527

Reference yield:

C9H11NS2*H3N (108654-39-3) → 4-[(10S)-dihydroartemisinin-10-oxy]benzaldehyde N4-(2,5-dimethylphenyl)thiosemicarbazone (1309469-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium monochloroacetic acid / ethanol / 0.5 h / 20 °C

1.2: 1 h / 20 °C

2.1: acetic acid / ethanol / 2 h / 20 °C

With sodium monochloroacetic acid; acetic acid; In ethanol;

DOI:10.3390/molecules16064527

Reference yield:

dihydroartemisinin-O-trifluoroacetic ester (286851-11-4) → 4-[(10S)-dihydroartemisinin-10-oxy]benzaldehyde N4-(2,5-dimethylphenyl)thiosemicarbazone (1309469-87-1)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 12 h / -5 - 0 °C

2: acetic acid / ethanol / 2 h / 20 °C

With acetic acid; In ethanol; dichloromethane;

DOI:10.3390/molecules16064527

upstream raw materials:

C₉H₁₁NS₂*H₃N

dihydroartemisinin-O-trifluoroacetic ester

(10S)-10-(4-formylphenyl)dihydroartemisinin

4-(2',5'-Dimethylphenyl)-thiosemicarbazid

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