2-butyl-1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-(trifluoromethyl)imidazole

Base Information

Chemical Name:2-butyl-1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-(trifluoromethyl)imidazole
CAS No.:114798-96-8
Molecular Formula:C₂₃H₂₃F₃N₂O₃
Molecular Weight:432.442
Hs Code.:

Synonyms:2-butyl-1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-(trifluoromethyl)imidazole

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Chemical Property of 2-butyl-1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-(trifluoromethyl)imidazole

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Technology Process of 2-butyl-1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-(trifluoromethyl)imidazole

There total 14 articles about 2-butyl-1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-(trifluoromethyl)imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 114772-63-3
1-<<2'-(tert-butoxycarbonyl)biphenyl-4-yl>methyl>-2-butyl-5-<<(2-methoxyethoxy)methoxy>methyl>-4-(trifluoromethyl)imidazole

: 114798-96-8
2-butyl-1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-(trifluoromethyl)imidazole

Guidance literature:: With tetrafluoroboric acid; In acetonitrile; at 25 ℃; for 18h;
DOI:10.1021/jm00112a031

Reference yield:

: 57598-33-1
2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline

: 114798-96-8
2-butyl-1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-(trifluoromethyl)imidazole

Guidance literature:: Multi-step reaction with 9 steps

1: tetrahydrofuran / 2 h / 20 °C

2: 88 percent / 4.5 N aq. HCl / 12 h / Heating

3: oxalyl chloride / CH₂Cl₂ / 3 h / 25 °C

4: tetrahydrofuran / 1 h / 25 °C

5: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

6: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

7: 1.) n-BuLi, t-butyl alcohol / 1.) THF, 0 deg C, 2.) 25 deg C, 16 h

8: 1.) cadimium, 2.) hexamethylphosphoric triamide, copper(I) bromide / 1.) DMF, 25 deg C, 2 h, 2.) DMF, 70-75 deg C, 6 h

9: 80 percent / 1.5 M tetrafluoroboric acid / acetonitrile / 18 h / 25 °C

With hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; N-Bromosuccinimide; tetrafluoroboric acid; n-butyllithium; oxalyl dichloride; sodium methylate; copper(I) bromide; cadmium; tert-butyl alcohol; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; acetonitrile;
DOI:10.1021/jm00112a031

Reference yield:

: 7148-03-0
o-tolylbenzoic acid

: 114798-96-8
2-butyl-1-<(2'-carboxylbiphenyl-4-yl)methyl>-5-(hydroxymethyl)-4-(trifluoromethyl)imidazole

Guidance literature:: Multi-step reaction with 7 steps

1: oxalyl chloride / CH₂Cl₂ / 3 h / 25 °C

2: tetrahydrofuran / 1 h / 25 °C

3: N-bromosuccinimide, dibenzoyl peroxide / CCl₄ / 3 h / Heating

4: 1.) sodium methoxide / 1.) DMF, 25 deg C, 0.25 h, 2.) DMF, 40 deg C, 4 h

5: 1.) n-BuLi, t-butyl alcohol / 1.) THF, 0 deg C, 2.) 25 deg C, 16 h

6: 1.) cadimium, 2.) hexamethylphosphoric triamide, copper(I) bromide / 1.) DMF, 25 deg C, 2 h, 2.) DMF, 70-75 deg C, 6 h

7: 80 percent / 1.5 M tetrafluoroboric acid / acetonitrile / 18 h / 25 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; N-Bromosuccinimide; tetrafluoroboric acid; n-butyllithium; oxalyl dichloride; sodium methylate; copper(I) bromide; cadmium; tert-butyl alcohol; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; dichloromethane; acetonitrile;
DOI:10.1021/jm00112a031