N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-ethynylbenzamide

Base Information

Chemical Name:N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-ethynylbenzamide
CAS No.:1609678-68-3
Molecular Formula:C₂₃H₂₄F₃N₃O
Molecular Weight:415.458
Hs Code.:

Synonyms:N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-ethynylbenzamide

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Chemical Property of N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-ethynylbenzamide

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Technology Process of N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-ethynylbenzamide

There total 7 articles about N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-ethynylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 630125-91-6
4-(4-ethylpiperazin-1-ylmethyl)-3-trifluoromethylphenylamine

: 10601-99-7
3-ethynylbenzoic acid

: 1609678-68-3
N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-ethynylbenzamide

Guidance literature:: With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 15h;

Reference yield: 46.6%

: 630125-91-6
4-(4-ethylpiperazin-1-ylmethyl)-3-trifluoromethylphenylamine

: 143587-37-5
3-ethynylbenzoyl chloride

: 1609678-68-3
N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-ethynylbenzamide

Guidance literature:: With pyridine; at 90 ℃;

Reference yield:

: 618-51-9
3-Iodobenzoic acid

: 1609678-68-3
N-{4-[(4-ethylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}-3-ethynylbenzamide

Guidance literature:: Multi-step reaction with 5 steps

1: sulfuric acid / 2.5 h / Reflux; Inert atmosphere

2: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 18 h / 20 °C / Inert atmosphere

3: methanol; sodium hydroxide; water / 1 h / 0 - 20 °C

4: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 0 - 20 °C

5: pyridine / 90 °C

With pyridine; methanol; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; oxalyl dichloride; sulfuric acid; water; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In tetrahydrofuran; dichloromethane;