2-((4-ethylpiperazin-1-yl)methyl)-4-oxo-3-phenyl-3,4-dihydroquinazoline-6-carbonitrile

Base Information

Chemical Name:2-((4-ethylpiperazin-1-yl)methyl)-4-oxo-3-phenyl-3,4-dihydroquinazoline-6-carbonitrile
CAS No.:1613465-21-6
Molecular Formula:C₂₂H₂₃N₅O
Molecular Weight:373.458
Hs Code.:

Synonyms:2-((4-ethylpiperazin-1-yl)methyl)-4-oxo-3-phenyl-3,4-dihydroquinazoline-6-carbonitrile

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Chemical Property of 2-((4-ethylpiperazin-1-yl)methyl)-4-oxo-3-phenyl-3,4-dihydroquinazoline-6-carbonitrile

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Technology Process of 2-((4-ethylpiperazin-1-yl)methyl)-4-oxo-3-phenyl-3,4-dihydroquinazoline-6-carbonitrile

There total 5 articles about 2-((4-ethylpiperazin-1-yl)methyl)-4-oxo-3-phenyl-3,4-dihydroquinazoline-6-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 5308-25-8
4-ethylpiperazine

: 1613465-80-7
2-(chloromethyl)-4-oxo-3-phenyl-3,4-dihydroquinazoline-6-carbonitrile

: 1613465-21-6
2-((4-ethylpiperazin-1-yl)methyl)-4-oxo-3-phenyl-3,4-dihydroquinazoline-6-carbonitrile

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; at 80 ℃; Microwave irradiation;
DOI:10.1021/jm501203v

Reference yield:

: 159847-81-1
methyl 2-AMINO-5-CYANOBENZOATE

: 1613465-21-6
2-((4-ethylpiperazin-1-yl)methyl)-4-oxo-3-phenyl-3,4-dihydroquinazoline-6-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: lithium hydroxide / tetrahydrofuran; water / 3 h / 20 °C

2: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

3: trichlorophosphate / acetonitrile / 150 °C / Inert atmosphere; Microwave irradiation

4: potassium iodide; potassium carbonate / acetonitrile / 80 °C / Microwave irradiation

With potassium carbonate; triethylamine; potassium iodide; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm501203v

Reference yield:

: 33348-34-4
4-amino-3-iodobenzonitrile

: 1613465-21-6
2-((4-ethylpiperazin-1-yl)methyl)-4-oxo-3-phenyl-3,4-dihydroquinazoline-6-carbonitrile

Guidance literature:: Multi-step reaction with 5 steps

1: palladium diacetate; 1,1'-bis-(diphenylphosphino)ferrocene; triethylamine; potassium carbonate / acetonitrile / 12 h / 75 °C / 760.05 Torr

2: lithium hydroxide / tetrahydrofuran; water / 3 h / 20 °C

3: triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

4: trichlorophosphate / acetonitrile / 150 °C / Inert atmosphere; Microwave irradiation

5: potassium iodide; potassium carbonate / acetonitrile / 80 °C / Microwave irradiation

With 1,1'-bis-(diphenylphosphino)ferrocene; palladium diacetate; potassium carbonate; triethylamine; potassium iodide; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1021/jm501203v