6,7-Dimethoxy-1-methyl-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline

Base Information

Chemical Name:6,7-Dimethoxy-1-methyl-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline
CAS No.:14165-85-6
Molecular Formula:C₁₉H₂₃NO₄S
Molecular Weight:361.462
Hs Code.:
DSSTox Substance ID:DTXSID401322392
ChEMBL ID:CHEMBL1412148
Mol file:14165-85-6.mol

Synonyms:14165-85-6;6,7-dimethoxy-1-methyl-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline;6,7-dimethoxy-1-methyl-2-(4-methylphenyl)sulfonyl-3,4-dihydro-1H-isoquinoline;ChemDiv3_002510;Oprea1_212045;MLS001181855;CHEMBL1412148;HUIUFNOUWOJTJG-UHFFFAOYSA-N;DTXSID401322392;HMS1480C02;HMS2886B08;CCG-18990;STK831318;AKOS000549524;PD162860;SMR000567524;EU-0042680;CS-003/03962041;SR-01000473260;SR-01000473260-1;BRD-A23522783-001-01-4;F0915-3904;6,7-dimethoxy-1-methyl-2-tosyl-1,2,3,4-tetrahydroisoquinoline

Suppliers and Price of 6,7-Dimethoxy-1-methyl-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of 6,7-Dimethoxy-1-methyl-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline

Chemical Property:

Melting Point:150 °C
Boiling Point:506.0±60.0 °C(Predicted)
PKA:-6.99±0.40(Predicted)
Density:1.209±0.06 g/cm3(Predicted)
XLogP3:3.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:361.13477939
Heavy Atom Count:25
Complexity:538

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1C2=CC(=C(C=C2CCN1S(=O)(=O)C3=CC=C(C=C3)C)OC)OC

Technology Process of 6,7-Dimethoxy-1-methyl-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline

There total 4 articles about 6,7-Dimethoxy-1-methyl-2-[(4-methylphenyl)sulfonyl]-1,2,3,4-tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 14165-67-4
N-(3,4-dimethoxyphenethyl)-4-methylbenzenesulfonamide

: 75-07-0,9002-91-9
acetaldehyde

: 14165-85-6
1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-methylphenyl)sulfonyl]-1-methylisoquinoline

Guidance literature:: With 12-tungstophosphoric acid hydrate; In acetonitrile; for 1h; Reflux; Green chemistry;
DOI:10.1016/j.cclet.2013.06.019

Reference yield:

: 120-20-7
2-(3,4-dimethoxyphenyl)-ethylamine

: 14165-85-6
1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-methylphenyl)sulfonyl]-1-methylisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / dichloromethane

2: trifluoroacetic acid / 0.5 h / Reflux

With sodium carbonate; trifluoroacetic acid; In dichloromethane; 2: |Pictet-Spengler Synthesis;
DOI:10.1007/s12272-013-0111-9

Reference yield:

: 98-59-9
p-toluenesulfonyl chloride

: 14165-85-6
1,2,3,4-tetrahydro-6,7-dimethoxy-2-[(4-methylphenyl)sulfonyl]-1-methylisoquinoline

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate / dichloromethane

2: trifluoroacetic acid / 0.5 h / Reflux

With sodium carbonate; trifluoroacetic acid; In dichloromethane; 2: |Pictet-Spengler Synthesis;
DOI:10.1007/s12272-013-0111-9