3-(8-cyanoquinolin-4-ylamino)-4-(4-fluorophenyl)pyrrolidine-1-carboxylic acid tert-butyl ester

Base Information

Chemical Name:3-(8-cyanoquinolin-4-ylamino)-4-(4-fluorophenyl)pyrrolidine-1-carboxylic acid tert-butyl ester
CAS No.:1357072-97-9
Molecular Formula:C₂₅H₂₅FN₄O₂
Molecular Weight:432.498
Hs Code.:

Synonyms:3-(8-cyanoquinolin-4-ylamino)-4-(4-fluorophenyl)pyrrolidine-1-carboxylic acid tert-butyl ester

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Chemical Property of 3-(8-cyanoquinolin-4-ylamino)-4-(4-fluorophenyl)pyrrolidine-1-carboxylic acid tert-butyl ester

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Technology Process of 3-(8-cyanoquinolin-4-ylamino)-4-(4-fluorophenyl)pyrrolidine-1-carboxylic acid tert-butyl ester

There total 1 articles about 3-(8-cyanoquinolin-4-ylamino)-4-(4-fluorophenyl)pyrrolidine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1185105-46-7
tert-butyl (3S*,4R*)-3-amino-4-(4-fluorophenyl)pyrrolidine-1-carboxylate

: 132664-45-0
4-chloro-8-cyanoquinoline

: 1357072-97-9
3-(8-cyanoquinolin-4-ylamino)-4-(4-fluorophenyl)pyrrolidine-1-carboxylic acid tert-butyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 - 100 ℃; for 168h;

Reference yield:

: 1357072-97-9
3-(8-cyanoquinolin-4-ylamino)-4-(4-fluorophenyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1357072-98-0
tert-butyl 3-{[8-(aminocarbonyl)quinolin-4-yl]amino}-4-(4-fluorophenyl)pyrrolidine-1-carboxylate

Guidance literature:: With dihydrogen peroxide; potassium carbonate; In dimethyl sulfoxide; at 50 ℃;

Reference yield:

: 1357072-97-9
3-(8-cyanoquinolin-4-ylamino)-4-(4-fluorophenyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1357071-02-3
4-((4-(4-fluorophenyl)pyrrolidin-3-yl)amino)quinoline-8-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 50 °C

2: hydrogenchloride / 1,4-dioxane / 0.5 h

With hydrogenchloride; dihydrogen peroxide; potassium carbonate; In 1,4-dioxane; dimethyl sulfoxide;