(2R,4aR,6S,7R,8R,8aR)-7,8-Bis-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine-6-carbaldehyde

Base Information

Chemical Name:(2R,4aR,6S,7R,8R,8aR)-7,8-Bis-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine-6-carbaldehyde
CAS No.:83416-95-9
Molecular Formula:C₂₈H₂₈O₆
Molecular Weight:460.527
Hs Code.:

Synonyms:(2R,4aR,6S,7R,8R,8aR)-7,8-Bis-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine-6-carbaldehyde

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Chemical Property of (2R,4aR,6S,7R,8R,8aR)-7,8-Bis-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine-6-carbaldehyde

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Technology Process of (2R,4aR,6S,7R,8R,8aR)-7,8-Bis-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine-6-carbaldehyde

There total 6 articles about (2R,4aR,6S,7R,8R,8aR)-7,8-Bis-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine-6-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20770-84-7,113566-69-1,113566-70-4
2,3-di-O-benzyl-4,6-O-benzylidene-D-glucopyranose

: 83416-95-9
(2R,4aR,6S,7R,8R,8aR)-7,8-Bis-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine-6-carbaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent

3: DIBAL

4: 70 percent / (-)-DET, Ti(i-PrO)4, TBHP / CH₂Cl₂ / -20 °C

5: 1.) (n-Bu)4N⁺F^-, 2.) NaH / 2.) DMF

6: NaIO₄

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium periodate; tetrabutyl ammonium fluoride; sodium hydride; diisobutylaluminium hydride; (-)-diethyl tartrate; In dichloromethane;
DOI:10.1021/ja00387a062

Reference yield:

: 83416-98-2
(E)-(4S,5R)-4,5-Bis-benzyloxy-5-((2R,4R,5R)-5-hydroxy-2-phenyl-[1,3]dioxan-4-yl)-pent-2-enoic acid ethyl ester

: 83416-95-9
(2R,4aR,6S,7R,8R,8aR)-7,8-Bis-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine-6-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

2: DIBAL

3: 70 percent / (-)-DET, Ti(i-PrO)4, TBHP / CH₂Cl₂ / -20 °C

4: 1.) (n-Bu)4N⁺F^-, 2.) NaH / 2.) DMF

5: NaIO₄

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium periodate; tetrabutyl ammonium fluoride; sodium hydride; diisobutylaluminium hydride; (-)-diethyl tartrate; In dichloromethane;
DOI:10.1021/ja00387a062

Reference yield:

: 83417-00-9
(E)-(4S,5R)-4,5-Bis-benzyloxy-5-((2R,4S,5R)-2-phenyl-5-triethylsilanyloxy-[1,3]dioxan-4-yl)-pent-2-en-1-ol

: 83416-95-9
(2R,4aR,6S,7R,8R,8aR)-7,8-Bis-benzyloxy-2-phenyl-hexahydro-pyrano[3,2-d][1,3]dioxine-6-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 70 percent / (-)-DET, Ti(i-PrO)4, TBHP / CH₂Cl₂ / -20 °C

2: 1.) (n-Bu)4N⁺F^-, 2.) NaH / 2.) DMF

3: NaIO₄

With titanium(IV) isopropylate; tert.-butylhydroperoxide; sodium periodate; tetrabutyl ammonium fluoride; sodium hydride; (-)-diethyl tartrate; In dichloromethane;
DOI:10.1021/ja00387a062