(S)-9-methoxy-3-[4-(2-pyrrolidin-1-yl-ethoxy)benzyl]-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine

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Chemical Name:(S)-9-methoxy-3-[4-(2-pyrrolidin-1-yl-ethoxy)benzyl]-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine
CAS No.:1208307-99-6
Molecular Formula:C₃₀H₃₆N₂O₅S
Molecular Weight:536.692
Hs Code.:

Synonyms:(S)-9-methoxy-3-[4-(2-pyrrolidin-1-yl-ethoxy)benzyl]-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine

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Chemical Property of (S)-9-methoxy-3-[4-(2-pyrrolidin-1-yl-ethoxy)benzyl]-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine

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Technology Process of (S)-9-methoxy-3-[4-(2-pyrrolidin-1-yl-ethoxy)benzyl]-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine

There total 10 articles about (S)-9-methoxy-3-[4-(2-pyrrolidin-1-yl-ethoxy)benzyl]-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

: 5050-41-9
N-(2-chloroethyl)-pyrrolidine

: 1208307-91-8
(S)-4-((9-methoxy-4-tosyl-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepin-3-yl)methyl)phenol

: 1208307-99-6
(S)-9-methoxy-3-[4-(2-pyrrolidin-1-yl-ethoxy)benzyl]-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine

Guidance literature:: With potassium carbonate; In acetone; at 70 ℃; for 3h;
DOI:10.1016/j.bmcl.2009.10.115

Reference yield:

: 1208307-84-9
(S)-N-(2-(benzyloxy)-3-methoxybenzyl)-N-(1-(4-(benzyloxy)phenyl)-3-hydroxypropan-2-yl)-4-methylbenzenesulfonamide

: 1208307-99-6
(S)-9-methoxy-3-[4-(2-pyrrolidin-1-yl-ethoxy)benzyl]-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 2585.81 Torr / Inert atmosphere

2: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

3: potassium carbonate / acetone / 5 h / Reflux; Inert atmosphere

With palladium 10% on activated carbon; hydrogen; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; acetone; 2: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2013.10.013

Reference yield:

: 1208307-87-2
(S)-N-(1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl)-N-(2-hydroxy-3-methoxybenzyl)-4-methylbenzenesulfonamide

: 1208307-99-6
(S)-9-methoxy-3-[4-(2-pyrrolidin-1-yl-ethoxy)benzyl]-4-(toluene-4-sulfonyl)-2,3,4,5-tetrahydrobenzo[f][1,4]oxazepine

Guidance literature:: Multi-step reaction with 2 steps

1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

2: potassium carbonate / acetone / 5 h / Reflux; Inert atmosphere

With potassium carbonate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; acetone; 1: |Mitsunobu Displacement;
DOI:10.1016/j.bmcl.2013.10.013