3-{4-[2-(pyrimidin-2-ylamino)ethyloxy]benzoylamino}-2(S)-benzenesulfonylaminopropionic acid tert-butyl ester

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Chemical Name:3-{4-[2-(pyrimidin-2-ylamino)ethyloxy]benzoylamino}-2(S)-benzenesulfonylaminopropionic acid tert-butyl ester
CAS No.:174665-29-3
Molecular Formula:C₂₆H₃₁N₅O₆S
Molecular Weight:541.628
Hs Code.:

Synonyms:3-{4-[2-(pyrimidin-2-ylamino)ethyloxy]benzoylamino}-2(S)-benzenesulfonylaminopropionic acid tert-butyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-{4-[2-(pyrimidin-2-ylamino)ethyloxy]benzoylamino}-2(S)-benzenesulfonylaminopropionic acid tert-butyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-{4-[2-(pyrimidin-2-ylamino)ethyloxy]benzoylamino}-2(S)-benzenesulfonylaminopropionic acid tert-butyl ester

There total 8 articles about 3-{4-[2-(pyrimidin-2-ylamino)ethyloxy]benzoylamino}-2(S)-benzenesulfonylaminopropionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 156185-89-6
tert-butyl (2S)-N-benzenesulfonyl-2,3-diaminopropionate

: 174665-28-2
4-[2-(pyrimidin-2-ylamino)ethyloxy]benzoic acid

: 174665-29-3
3-{4-[2-(pyrimidin-2-ylamino)ethyloxy]benzoylamino}-2(S)-benzenesulfonylaminopropionic acid tert-butyl ester

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; at 20 ℃; for 72h;
DOI:10.1021/jm000133v

Reference yield:

: 156185-87-4
N-phenylsulfonyl-L-asparagine

: 174665-29-3
3-{4-[2-(pyrimidin-2-ylamino)ethyloxy]benzoylamino}-2(S)-benzenesulfonylaminopropionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 24 percent / aq. NaOH; Br₂ / 0.83 h / 0 - 90 °C

2: H₂SO₄ / 1,2-dimethoxy-ethane / 24 h / -78 °C

3: 67 percent / N-methylmorpholine; HOBT; EDC / dimethylformamide / 72 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; sulfuric acid; bromine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide; 1: Hofmann degradation / 2: Addition / 3: Condensation;
DOI:10.1021/jm000133v

Reference yield:

: 56850-93-2
methyl 4-(2-Aminoethyloxy)benzoate

: 174665-29-3
3-{4-[2-(pyrimidin-2-ylamino)ethyloxy]benzoylamino}-2(S)-benzenesulfonylaminopropionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: DIPEA / dimethylformamide / 16 h / 80 °C

2: 65 percent / 1N NaOH / ethanol / 2 h / 60 °C

3: 67 percent / N-methylmorpholine; HOBT; EDC / dimethylformamide / 72 h / 20 °C

With 4-methyl-morpholine; sodium hydroxide; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; N-ethyl-N,N-diisopropylamine; In ethanol; N,N-dimethyl-formamide; 1: Condensation / 2: saponification / 3: Condensation;
DOI:10.1021/jm000133v