4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-[3'''-(trimethylstannyl)phenyl]-2,3-dihydro-1H-1,5-benzodiazepin-2-one

Base Information

Chemical Name:4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-[3'''-(trimethylstannyl)phenyl]-2,3-dihydro-1H-1,5-benzodiazepin-2-one
CAS No.:1453394-00-7
Molecular Formula:C₂₇H₂₆N₄OSn
Molecular Weight:541.24
Hs Code.:

Synonyms:4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-[3'''-(trimethylstannyl)phenyl]-2,3-dihydro-1H-1,5-benzodiazepin-2-one

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Chemical Property of 4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-[3'''-(trimethylstannyl)phenyl]-2,3-dihydro-1H-1,5-benzodiazepin-2-one

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Technology Process of 4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-[3'''-(trimethylstannyl)phenyl]-2,3-dihydro-1H-1,5-benzodiazepin-2-one

There total 11 articles about 4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-[3'''-(trimethylstannyl)phenyl]-2,3-dihydro-1H-1,5-benzodiazepin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1453393-56-0
8-(3'''-bromophenyl)-4-[3’-(1''H-imidazol-1''-yl)phenyl]-2,3-dihydro-1H-1,5-benzodiazepin-2-one

: 661-69-8
hexamethyldistannane

: 1453394-00-7
4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-[3'''-(trimethylstannyl)phenyl]-2,3-dihydro-1H-1,5-benzodiazepin-2-one

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 90 ℃; for 48h; Inert atmosphere;
DOI:10.1039/c3md00110e

Reference yield:

: 20691-72-9
4-iodo-2-nitroaniline

: 1453394-00-7
4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-[3'''-(trimethylstannyl)phenyl]-2,3-dihydro-1H-1,5-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: triethylamine; dmap / dichloromethane / 18 h / 20 °C

2: trifluoroacetic acid / dichloromethane / 3 h / 0 - 20 °C

3: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; N,N-dimethyl-formamide / 1.5 h / 110 °C

4: tin(II) chloride dihdyrate; pyridine / ethyl acetate / 6 h / 20 °C

5: toluene / 4 h / Reflux

6: trifluoroacetic acid / dichloromethane / 0.5 h / 0 - 20 °C

7: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 48 h / 90 °C / Inert atmosphere

With pyridine; dmap; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; potassium carbonate; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; toluene; 3: |Suzuki-Miyaura Coupling;
DOI:10.1039/c3md00110e

Reference yield:

: 1453393-21-9
4-(3’-bromophenyl)-1-(tert-butoxycarbonylamino)-2-nitrobenzene

: 1453394-00-7
4-[3’-(1''H-imidazol-1''-yl)phenyl]-8-[3'''-(trimethylstannyl)phenyl]-2,3-dihydro-1H-1,5-benzodiazepin-2-one

Guidance literature:: Multi-step reaction with 4 steps

1: tin(II) chloride dihdyrate; pyridine / ethyl acetate / 6 h / 20 °C

2: toluene / 4 h / Reflux

3: trifluoroacetic acid / dichloromethane / 0.5 h / 0 - 20 °C

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 48 h / 90 °C / Inert atmosphere

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; ethyl acetate; toluene;
DOI:10.1039/c3md00110e