2-(R)-3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-N-((S)-2-hydroxy-1-phenylethyl) propanamide

Base Information

Chemical Name:2-(R)-3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-N-((S)-2-hydroxy-1-phenylethyl) propanamide
CAS No.:1433194-37-6
Molecular Formula:C₂₁H₂₆ClNO₄
Molecular Weight:391.895
Hs Code.:

Synonyms:2-(R)-3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-N-((S)-2-hydroxy-1-phenylethyl) propanamide

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Chemical Property of 2-(R)-3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-N-((S)-2-hydroxy-1-phenylethyl) propanamide

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Technology Process of 2-(R)-3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-N-((S)-2-hydroxy-1-phenylethyl) propanamide

There total 3 articles about 2-(R)-3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-N-((S)-2-hydroxy-1-phenylethyl) propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

: 1433194-35-4
3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-propionic acid

: 20989-17-7
(2S)-2-phenylglycinol

: 1433194-36-5
2-(S)-3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-N-((S)-2-hydroxy-1-phenylethyl) propanamide

: 1433194-37-6
2-(R)-3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-N-((S)-2-hydroxy-1-phenylethyl) propanamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1002/cmdc.201200316

Reference yield:

: C₁₅H₁₉ClO₄

: 1433194-37-6
2-(R)-3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-N-((S)-2-hydroxy-1-phenylethyl) propanamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / ethanol / 20 h / 20 °C / 760.05 Torr

2: lithium hydroxide / water; tetrahydrofuran / 20 h / 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1002/cmdc.201200316

Reference yield:

: 901113-92-6
ethyl 3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-propionate

: 1433194-37-6
2-(R)-3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-N-((S)-2-hydroxy-1-phenylethyl) propanamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium hydroxide / water; tetrahydrofuran / 20 h / 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; triethylamine / dichloromethane / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In tetrahydrofuran; dichloromethane; water;
DOI:10.1002/cmdc.201200316