diethyl (1S,2S)-3-(dibenzylamino)-1-benzyloxy-2-hydroxypropylphosphonate

Base Information

Chemical Name:diethyl (1S,2S)-3-(dibenzylamino)-1-benzyloxy-2-hydroxypropylphosphonate
CAS No.:959596-50-0
Molecular Formula:C₂₈H₃₆NO₅P
Molecular Weight:497.571
Hs Code.:

Synonyms:diethyl (1S,2S)-3-(dibenzylamino)-1-benzyloxy-2-hydroxypropylphosphonate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl (1S,2S)-3-(dibenzylamino)-1-benzyloxy-2-hydroxypropylphosphonate

Chemical Property:

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Technology Process of diethyl (1S,2S)-3-(dibenzylamino)-1-benzyloxy-2-hydroxypropylphosphonate

There total 8 articles about diethyl (1S,2S)-3-(dibenzylamino)-1-benzyloxy-2-hydroxypropylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 959596-46-4
diethyl (1S,2S)-2,3-epoxy-1-benzyloxy-3-hydroxypropylphosphonate

: 103-49-1
dibenzylamine

: 959596-50-0
diethyl (1S,2S)-3-(dibenzylamino)-1-benzyloxy-2-hydroxypropylphosphonate

Guidance literature:: With calcium(II) trifluoromethanesulfonate; In acetonitrile; at 50 ℃; for 20h;
DOI:10.1016/j.tetasy.2007.09.003

Reference yield:

: 959596-45-3
diethyl (1S,2R)-1-benzyloxy-3-hydroxy-2-mezyloxypropylphosphonate

: 959596-50-0
diethyl (1S,2S)-3-(dibenzylamino)-1-benzyloxy-2-hydroxypropylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / potassium carbonate / ethanol / 20 h / 20 °C

2: 60 percent / calcium triflate / acetonitrile / 20 h / 50 °C

With potassium carbonate; calcium(II) trifluoromethanesulfonate; In ethanol; acetonitrile; 1: Williamson reaction;
DOI:10.1016/j.tetasy.2007.09.003

Reference yield:

: 959596-43-1
diethyl (1S,2R)-1-benzyloxy-2-hydroxy-3-trityloxypropylphosphonate

: 959596-50-0
diethyl (1S,2S)-3-(dibenzylamino)-1-benzyloxy-2-hydroxypropylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 20 h / 20 °C

2: 97 percent / TsOH / ethanol / 20 h / 20 °C / pH 3

3: 89 percent / potassium carbonate / ethanol / 20 h / 20 °C

4: 60 percent / calcium triflate / acetonitrile / 20 h / 50 °C

With dmap; potassium carbonate; toluene-4-sulfonic acid; calcium(II) trifluoromethanesulfonate; triethylamine; In ethanol; dichloromethane; acetonitrile; 3: Williamson reaction;
DOI:10.1016/j.tetasy.2007.09.003