9a'-phenyl-7',8',9',9a'-tetrahydro-5'H-spiro[cyclohexane-1,4'-thieno[2,3-g]indolizin]-5'-one

Base Information

Chemical Name:9a'-phenyl-7',8',9',9a'-tetrahydro-5'H-spiro[cyclohexane-1,4'-thieno[2,3-g]indolizin]-5'-one
CAS No.:1429308-69-9
Molecular Formula:C₂₁H₂₃NOS
Molecular Weight:337.486
Hs Code.:

Synonyms:9a'-phenyl-7',8',9',9a'-tetrahydro-5'H-spiro[cyclohexane-1,4'-thieno[2,3-g]indolizin]-5'-one

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Chemical Property of 9a'-phenyl-7',8',9',9a'-tetrahydro-5'H-spiro[cyclohexane-1,4'-thieno[2,3-g]indolizin]-5'-one

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Technology Process of 9a'-phenyl-7',8',9',9a'-tetrahydro-5'H-spiro[cyclohexane-1,4'-thieno[2,3-g]indolizin]-5'-one

There total 3 articles about 9a'-phenyl-7',8',9',9a'-tetrahydro-5'H-spiro[cyclohexane-1,4'-thieno[2,3-g]indolizin]-5'-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 99856-75-4
1-(thiophen-2-yl)cyclohexanecarbonitrile

: 3481-02-5
cyclopropyl phenyl ketone

: 1429308-69-9
9a'-phenyl-7',8',9',9a'-tetrahydro-5'H-spiro[cyclohexane-1,4'-thieno[2,3-g]indolizin]-5'-one

Guidance literature:: With tributylphosphine; boron trifluoride diethyl etherate; copper(I) bromide; In nitromethane; at 90 ℃; for 18h;
DOI:10.1039/c3cc40643a

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 1429308-69-9
9a'-phenyl-7',8',9',9a'-tetrahydro-5'H-spiro[cyclohexane-1,4'-thieno[2,3-g]indolizin]-5'-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / hexane / 4 h / 0 - 20 °C / Inert atmosphere

1.2: 0.17 h / 20 °C / Inert atmosphere

1.3: 0.5 h / 20 °C / Inert atmosphere

2.1: copper(I) bromide; boron trifluoride diethyl etherate; tributylphosphine / nitromethane / 18 h / 90 °C

With n-butyllithium; tributylphosphine; boron trifluoride diethyl etherate; copper(I) bromide; In nitromethane; hexane; 2.1: |Ritter Amidation;
DOI:10.1039/c3cc40643a

Reference yield:

: 20893-30-5
2-cyanomethylthiophene

: 628-77-3
1,5-diiodopentane

: 1429308-69-9
9a'-phenyl-7',8',9',9a'-tetrahydro-5'H-spiro[cyclohexane-1,4'-thieno[2,3-g]indolizin]-5'-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dimethyl sulfoxide / 0.5 h / 20 °C / Inert atmosphere

1.2: 2 h / 20 °C / Inert atmosphere

2.1: copper(I) bromide; boron trifluoride diethyl etherate; tributylphosphine / nitromethane / 18 h / 90 °C

With tributylphosphine; boron trifluoride diethyl etherate; sodium hydride; copper(I) bromide; In nitromethane; dimethyl sulfoxide; 2.1: |Ritter Amidation;
DOI:10.1039/c3cc40643a