2-amino-3',6'-bis(1-(2-nitrophenyl)ethoxy)spiro[isoindoline-1,9'-xanthen]-3-one

Base Information

• Chemical Name: 2-amino-3',6'-bis(1-(2-nitrophenyl)ethoxy)spiro[isoindoline-1,9'-xanthen]-3-one
• CAS No.: 1269423-41-7
• Molecular Formula: C₃₆H₂₈N₄O₈
• Molecular Weight: 644.64
• Mol file: 1269423-41-7.mol

Synonyms:2-amino-3',6'-bis(1-(2-nitrophenyl)ethoxy)spiro[isoindoline-1,9'-xanthen]-3-one

Chemical Property of 2-amino-3',6'-bis(1-(2-nitrophenyl)ethoxy)spiro[isoindoline-1,9'-xanthen]-3-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-amino-3',6'-bis(1-(2-nitrophenyl)ethoxy)spiro[isoindoline-1,9'-xanthen]-3-one

There total 4 articles about 2-amino-3',6'-bis(1-(2-nitrophenyl)ethoxy)spiro[isoindoline-1,9'-xanthen]-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

α-methyl-o-nitrobenzyl bromide (69642-00-8) + 2-amino-3′,6′-dihydroxyspiro[isoindoline-1,9′-xanthen]-3-one (98907-26-7) → 2-amino-3',6'-bis(1-(2-nitrophenyl)ethoxy)spiro[isoindoline-1,9'-xanthen]-3-one (1269423-41-7)

Guidance literature:

With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 6h; Inert atmosphere;

DOI:10.1002/chem.201001923

Reference yield:

1-(2-nitrophenyl)ethan-1-ol (80379-10-8,108530-03-6,142631-59-2,3205-25-2) → 2-amino-3',6'-bis(1-(2-nitrophenyl)ethoxy)spiro[isoindoline-1,9'-xanthen]-3-one (1269423-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-Bromosuccinimide / tetrachloromethane / 0.5 h / 40 °C / Inert atmosphere; Schlenk technique

1.2: 40 - 85 °C / Inert atmosphere; Schlenk technique

2.1: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With N-Bromosuccinimide; caesium carbonate; In tetrachloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.cclet.2017.07.016

Reference yield:

fluorescein (2321-07-5,126605-73-0) → 2-amino-3',6'-bis(1-(2-nitrophenyl)ethoxy)spiro[isoindoline-1,9'-xanthen]-3-one (1269423-41-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine hydrate / methanol / 90 °C / Inert atmosphere; Reflux

2: caesium carbonate / N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With caesium carbonate; hydrazine hydrate; In methanol; N,N-dimethyl-formamide;

DOI:10.1016/j.cclet.2017.07.016

upstream raw materials:

α-methyl-o-nitrobenzyl bromide

2-amino-3′,6′-dihydroxyspiro[isoindoline-1,9′-xanthen]-3-one

fluorescein free acid

1-(2-nitrophenyl)ethan-1-ol

Downstream raw materials:

fluorescein free acid