di-tert-butyl 1-(2-oxo-1-(p-tolyl)cyclohexyl)hydrazine-1,2-dicarboxylate

Base Information

• Chemical Name: di-tert-butyl 1-(2-oxo-1-(p-tolyl)cyclohexyl)hydrazine-1,2-dicarboxylate
• CAS No.: 1070898-78-0
• Molecular Formula: C₂₃H₃₄N₂O₅
• Molecular Weight: 418.533
• Mol file: 1070898-78-0.mol

Synonyms:di-tert-butyl 1-(2-oxo-1-(p-tolyl)cyclohexyl)hydrazine-1,2-dicarboxylate

Chemical Property of di-tert-butyl 1-(2-oxo-1-(p-tolyl)cyclohexyl)hydrazine-1,2-dicarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of di-tert-butyl 1-(2-oxo-1-(p-tolyl)cyclohexyl)hydrazine-1,2-dicarboxylate

There total 2 articles about di-tert-butyl 1-(2-oxo-1-(p-tolyl)cyclohexyl)hydrazine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

di-tert-butyl (E)-azodicarboxylate (870-50-8) + 2-methoxy-2-(4-methylphenyl)cyclohexanone (190256-58-7) → di-tert-butyl 1-(2-oxo-1-(p-tolyl)cyclohexyl)hydrazine-1,2-dicarboxylate (1070898-78-0)

Guidance literature:

With N,N,N,N,N,N-hexamethylphosphoric triamide; samarium diiodide; In tetrahydrofuran; at 20 ℃; for 1h;

DOI:10.1016/j.tetlet.2008.07.123

Reference yield:

2-(4-methylphenyl)cyclohexanone (52776-14-4) + di-tert-butyl-diazodicarboxylate (870-50-8) → di-tert-butyl 1-(2-oxo-1-(p-tolyl)cyclohexyl)hydrazine-1,2-dicarboxylate (1070898-78-0)

Guidance literature:

With (R)-3,3'-bis(2,4,6-triisopropylphenyl)-1,1'-binaphthyl-2,2'-diylhydrogenphosphate; In neat (no solvent); at 45 ℃; for 60h; enantioselective reaction;

DOI:10.1021/jacs.5b00229

upstream raw materials:

di-tert-butyl (E)-azodicarboxylate

2-methoxy-2-(4-methylphenyl)cyclohexanone

2-(4-methylphenyl)cyclohexanone

di-tert-butyl-diazodicarboxylate