(3S)-3-<(N-benzyloxycarbonyl)-L-leucinyl>amino-1-hydropxy-5-methyl-2-hexanone

Base Information

Chemical Name:(3S)-3-<(N-benzyloxycarbonyl)-L-leucinyl>amino-1-hydropxy-5-methyl-2-hexanone
CAS No.:216489-70-2
Molecular Formula:C₂₁H₃₂N₂O₅
Molecular Weight:392.495
Hs Code.:

Synonyms:(3S)-3-<(N-benzyloxycarbonyl)-L-leucinyl>amino-1-hydropxy-5-methyl-2-hexanone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3S)-3-<(N-benzyloxycarbonyl)-L-leucinyl>amino-1-hydropxy-5-methyl-2-hexanone

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Technology Process of (3S)-3-<(N-benzyloxycarbonyl)-L-leucinyl>amino-1-hydropxy-5-methyl-2-hexanone

There total 6 articles about (3S)-3-<(N-benzyloxycarbonyl)-L-leucinyl>amino-1-hydropxy-5-methyl-2-hexanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 116614-39-2
(3S)-3-<(N-benzyloxycarbonyl)-L-leucinyl>amino-1-diazo-5-methyl-2-hexanone

: 216489-70-2
(3S)-3-<(N-benzyloxycarbonyl)-L-leucinyl>amino-1-hydropxy-5-methyl-2-hexanone

Guidance literature:: Multi-step reaction with 3 steps

1: aq. HBr / acetic acid; tetrahydrofuran / 0 °C

2: 1.04 g / KF / dimethylformamide / 16 h / Ambient temperature

3: 0.768 g / potassium bicarbonate / tetrahydrofuran / 18 h / Ambient temperature

With potassium fluoride; hydrogen bromide; potassium hydrogencarbonate; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(99)00011-5

Reference yield:

: 7801-71-0
N-benzyloxycarbonyl-L-leucyl-L-leucine

: 216489-70-2
(3S)-3-<(N-benzyloxycarbonyl)-L-leucinyl>amino-1-hydropxy-5-methyl-2-hexanone

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) N-methylmorpholine, isobutyl chloroformate / 1) THF, -40 deg C, 15 min; 2) THF, ether, 0 deg C, 16 h

2: aq. HBr / acetic acid; tetrahydrofuran / 0 °C

3: 1.04 g / KF / dimethylformamide / 16 h / Ambient temperature

4: 0.768 g / potassium bicarbonate / tetrahydrofuran / 18 h / Ambient temperature

With 4-methyl-morpholine; potassium fluoride; hydrogen bromide; potassium hydrogencarbonate; isobutyl chloroformate; In tetrahydrofuran; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(99)00011-5

Reference yield:

: C₂₅H₃₈N₂O₇

: 216489-70-2
(3S)-3-<(N-benzyloxycarbonyl)-L-leucinyl>amino-1-hydropxy-5-methyl-2-hexanone

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran / 0 °C

2: HBr, AcOH / tetrahydrofuran / 0.08 h

3: 1.) KF, 2.) 1 M aq. K₂CO₃ / 1.) DMF, RT, 2.) THF

With potassium fluoride; hydrogen bromide; potassium carbonate; acetic acid; In tetrahydrofuran;
DOI:10.1021/jm980249f