2-bromo-4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Base Information

Chemical Name:2-bromo-4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol
CAS No.:1245635-39-5
Molecular Formula:C₁₃H₁₈BBrO₃
Molecular Weight:312.999
Hs Code.:

Synonyms:2-bromo-4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-bromo-4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

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Technology Process of 2-bromo-4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

There total 4 articles about 2-bromo-4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 76-09-5
2,3-dimethyl-2,3-butane diol

: 1245635-38-4
(3-bromo-2-hydroxy-5-methylphenyl)boronic acid

: 1245635-39-5
2-bromo-4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Guidance literature:: In dichloromethane; Inert atmosphere;
DOI:10.1002/anie.201002191

Reference yield:

: 2432-14-6
3,5-dibromo-4-hydroxytoluene

: 1245635-39-5
2-bromo-4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / 0 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

2.2: -78 - 20 °C / Inert atmosphere

3.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 0 - 20 °C

4.1: dichloromethane

With n-butyllithium; chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; sodium iodide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2013.03.016

Reference yield:

: 1245635-36-2
1,3-dibromo-2-(methoxymethoxy)-5-methylbenzene

: 1245635-39-5
2-bromo-4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: sodium iodide; chloro-trimethyl-silane / acetonitrile / 0 - 20 °C

3.1: dichloromethane

With n-butyllithium; chloro-trimethyl-silane; sodium iodide; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1016/j.tet.2013.03.016