N-<(S)-α-ethylbenzyl>pyruvamide

Base Information

• Chemical Name: N-<(S)-α-ethylbenzyl>pyruvamide
• CAS No.: 77855-49-3
• Molecular Formula: C₁₂H₁₅NO₂
• Molecular Weight: 205.257
• Mol file: 77855-49-3.mol

Synonyms:N-<(S)-α-ethylbenzyl>pyruvamide

Chemical Property of N-<(S)-α-ethylbenzyl>pyruvamide

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of N-<(S)-α-ethylbenzyl>pyruvamide

There total 1 articles about N-<(S)-α-ethylbenzyl>pyruvamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 16.0%

(R)-1-phenylpropylamine (3789-59-1) + 2-oxo-propionic acid (127-17-3) → N-<(S)-α-ethylbenzyl>pyruvamide (77855-49-3)

Guidance literature:

With 1-hydroxy-pyrrolidine-2,5-dione; dicyclohexyl-carbodiimide; In ethyl acetate; at 0 - 20 ℃; for 14h;

DOI:10.1246/bcsj.56.298

Reference yield: 37.0%

N-<(S)-α-ethylbenzyl>pyruvamide (77855-49-3) → 2-[(Z)-Hydroxyimino]-N-((S)-1-phenyl-propyl)-propionamide

Guidance literature:

With pyridine; hydroxylamine hydrochloride; In ethanol; for 3h; Heating;

DOI:10.1246/bcsj.61.1425

Reference yield:

N-<(S)-α-ethylbenzyl>pyruvamide (77855-49-3) → 2-Amino-N-((S)-1-phenyl-propyl)-propionamide

Guidance literature:

Multi-step reaction with 2 steps

1: 37 percent / hydroxylamine hydrochloride, pyridine / ethanol / 3 h / Heating

2: hydrogen / 10 percent palladium hydroxide on charcoal / methanol / 30 °C

With pyridine; hydroxylamine hydrochloride; hydrogen; palladium hydroxide - carbon; In methanol; ethanol;

DOI:10.1246/bcsj.61.1425

upstream raw materials:

(R)-1-phenylpropylamine

2-oxo-propionic acid

Downstream raw materials:

(S)-2-Hydroxy-N-((S)-1-phenyl-propyl)-propionamide

(R)-2-Hydroxy-N-((S)-1-phenyl-propyl)-propionamide