3-(Trifluoromethyl)bicyclo[1.1.1]pentan-1-aminehydrochloride

Base Information

Chemical Name:3-(Trifluoromethyl)bicyclo[1.1.1]pentan-1-aminehydrochloride
CAS No.:262852-11-9
Molecular Formula:C₆H₈F₃N*ClH
Molecular Weight:187.592
Hs Code.:2921309990
Mol file:262852-11-9.mol

Synonyms:3-(trifluoromethyl)-bicyclo[1.1.1]pentan-1-amine hydrochloride

Suppliers and Price of 3-(Trifluoromethyl)bicyclo[1.1.1]pentan-1-aminehydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3-(Trifluoromethyl)bicyclo[1.1.1]pentan-1-aminehydrochloride 95+%
5g
$ 10416.00

Crysdot
3-(Trifluoromethyl)bicyclo[1.1.1]pentan-1-aminehydrochloride 95+%
1g
$ 4167.00

American Custom Chemicals Corporation
3-(TRIFLUOROMETHYL)BICYCLO[1.1.1]PENTAN-1-AMINE HYDROCHLORIDE 95.00%
5MG
$ 504.93

Activate Scientific
3-(Trifluoromethyl)bicyclo[1.1.1]pentan-1-amine HCl 95%
1 g
$ 1843.00

Total 11 raw suppliers

Chemical Property of 3-(Trifluoromethyl)bicyclo[1.1.1]pentan-1-aminehydrochloride

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

3-(Trifluoromethyl)bicyclo[1.1.1]pentan-1-aminehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(Trifluoromethyl)bicyclo[1.1.1]pentan-1-aminehydrochloride

There total 4 articles about 3-(Trifluoromethyl)bicyclo[1.1.1]pentan-1-aminehydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: tert-butyl (3-(trifiuoromethyl)bicyclo[1.1.1]pentan-1-yl)carbamate

: 262852-11-9
3-(trifluoromethyl)-bicyclo[1.1.1]pentan-1-amine hydrochloride

Guidance literature:: With hydrogenchloride; In 1,4-dioxane; ethyl acetate; at 20 ℃;

Reference yield: 60.0%

: 887144-94-7
Togni's reagent II

: 35634-10-7
[1.1.1]propellane

: 262852-11-9
3-(trifluoromethyl)-bicyclo[1.1.1]pentan-1-amine hydrochloride

Guidance literature:: Togni's reagent II; [1.1.1]propellane; With copper acetylacetonate; tert-butyl carbazate; N,N,N′,N′-tetramethyl-N″-tert-butylguanidine; In 1,4-dioxane; Irradiation;

With hydrogenchloride; In 1,4-dioxane;
DOI:10.1038/s41586-020-2060-z

Reference yield:

: 119934-12-2
1-(trifluoromethyl)-3-iodobicyclo<1.1.1>pentane

: 262852-11-9
3-(trifluoromethyl)-bicyclo[1.1.1]pentan-1-amine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate; tert.-butyl lithium / diethyl ether; pentane / 0.5 h / -78 °C

1.2: 0.17 h / -78 - 20 °C

2.1: diphenyl phosphoryl azide; triethylamine / 4 h / 30 - 90 °C / Inert atmosphere

3.1: hydrogenchloride / 1,4-dioxane; ethyl acetate / 20 °C

With hydrogenchloride; diphenyl phosphoryl azide; tert.-butyl lithium; sodium hydrogencarbonate; triethylamine; In 1,4-dioxane; diethyl ether; ethyl acetate; pentane;