(S,S)-N,N'-bis(2-hydroxy-1-phenylethyl)-2-diphenylmethylidenemalonamide

Base Information

Chemical Name:(S,S)-N,N'-bis(2-hydroxy-1-phenylethyl)-2-diphenylmethylidenemalonamide
CAS No.:1346538-15-5
Molecular Formula:C₃₂H₃₀N₂O₄
Molecular Weight:506.601
Hs Code.:

Synonyms:(S,S)-N,N'-bis(2-hydroxy-1-phenylethyl)-2-diphenylmethylidenemalonamide

Suppliers and Price of (S,S)-N,N'-bis(2-hydroxy-1-phenylethyl)-2-diphenylmethylidenemalonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S,S)-N,N'-bis(2-hydroxy-1-phenylethyl)-2-diphenylmethylidenemalonamide

Chemical Property:

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Technology Process of (S,S)-N,N'-bis(2-hydroxy-1-phenylethyl)-2-diphenylmethylidenemalonamide

There total 3 articles about (S,S)-N,N'-bis(2-hydroxy-1-phenylethyl)-2-diphenylmethylidenemalonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 20989-17-7
(2S)-2-phenylglycinol

: 111168-65-1
2-(diphenylmethylidene)malonic acid dichloride

: 1346538-15-5
(S,S)-N,N'-bis(2-hydroxy-1-phenylethyl)-2-diphenylmethylidenemalonamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 4h;
DOI:10.1016/j.tet.2011.09.106

Reference yield:

: 4472-94-0
2-(diphenylmethylidene)malonic acid

: 1346538-15-5
(S,S)-N,N'-bis(2-hydroxy-1-phenylethyl)-2-diphenylmethylidenemalonamide

Guidance literature:: Multi-step reaction with 2 steps

1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 °C

2: triethylamine / dichloromethane / 4 h / 0 - 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; In dichloromethane;
DOI:10.1016/j.tet.2011.09.106

Reference yield:

: 24824-36-0
diethyl 2,2-diphenylethene-1,1-dicarboxylate

: 1346538-15-5
(S,S)-N,N'-bis(2-hydroxy-1-phenylethyl)-2-diphenylmethylidenemalonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / methanol; water / 8 h / Reflux

1.2: 0 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 °C

3.1: triethylamine / dichloromethane / 4 h / 0 - 20 °C

With oxalyl dichloride; triethylamine; N,N-dimethyl-formamide; sodium hydroxide; In methanol; dichloromethane; water;
DOI:10.1016/j.tet.2011.09.106