methyl 9-[3-O-(5,5-di-tert-butyloxycarbonylpentyl)-2-O-p-methoxybenzyl-4,6-O-benzylidene-α-D-galactopyranosyloxy]-nonanoate

Base Information

Chemical Name:methyl 9-[3-O-(5,5-di-tert-butyloxycarbonylpentyl)-2-O-p-methoxybenzyl-4,6-O-benzylidene-α-D-galactopyranosyloxy]-nonanoate
CAS No.:364630-24-0
Molecular Formula:C₄₆H₆₈O₁₃
Molecular Weight:829.038
Hs Code.:

Synonyms:methyl 9-[3-O-(5,5-di-tert-butyloxycarbonylpentyl)-2-O-p-methoxybenzyl-4,6-O-benzylidene-α-D-galactopyranosyloxy]-nonanoate

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Chemical Property of methyl 9-[3-O-(5,5-di-tert-butyloxycarbonylpentyl)-2-O-p-methoxybenzyl-4,6-O-benzylidene-α-D-galactopyranosyloxy]-nonanoate

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Technology Process of methyl 9-[3-O-(5,5-di-tert-butyloxycarbonylpentyl)-2-O-p-methoxybenzyl-4,6-O-benzylidene-α-D-galactopyranosyloxy]-nonanoate

There total 9 articles about methyl 9-[3-O-(5,5-di-tert-butyloxycarbonylpentyl)-2-O-p-methoxybenzyl-4,6-O-benzylidene-α-D-galactopyranosyloxy]-nonanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

: 34957-73-8
methyl 9-hydroxynonanoate

: 206857-28-5
ethyl 2-O-p-methoxybenzyl-4,6-di-O-benzylidene-3-O-(5,5-di-tert-butyloxycarbonylpentyl)-1-thio-β-D-galactopyranoside

: 364630-25-1
methyl 9-[3-O-(5,5-di-tert-butyloxycarbonylpentyl)-2-O-p-methoxybenzyl-4,6-O-benzylidene-β-D-galactopyranosyloxy]-nonanoate

: 364630-24-0
methyl 9-[3-O-(5,5-di-tert-butyloxycarbonylpentyl)-2-O-p-methoxybenzyl-4,6-O-benzylidene-α-D-galactopyranosyloxy]-nonanoate

Guidance literature:: methyl 9-hydroxynonanoate; ethyl 2-O-p-methoxybenzyl-4,6-di-O-benzylidene-3-O-(5,5-di-tert-butyloxycarbonylpentyl)-1-thio-β-D-galactopyranoside; With 2,6-di-tert-butyl-4-methylpyridine; In toluene; at 22 ℃;

With dimethyl-(methylthio)-sulphonium trifluoromethanesulphonate; In toluene;
DOI:10.1016/S0968-0896(01)00015-3

Reference yield:

: 1125-88-8
benzaldehyde dimethyl acetal

: 364630-24-0
methyl 9-[3-O-(5,5-di-tert-butyloxycarbonylpentyl)-2-O-p-methoxybenzyl-4,6-O-benzylidene-α-D-galactopyranosyloxy]-nonanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 62 percent / p-toluenesulfonic acid / acetonitrile / 22 °C

2.1: 59 percent / NaH / dimethylformamide / 22 °C

3.1: 82 percent / t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran; dimethylformamide / 50 - 60 °C

4.1: 2,6-di-tert-butyl-4-methylpyridine / toluene / 22 °C

4.2: 40 percent / dimethyl(methylthio)sulfonium triflate / toluene

With 2,6-di-tert-butyl-4-methylpyridine; potassium tert-butylate; sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1016/S0968-0896(01)00015-3

Reference yield:

: 172146-95-1
ethyl 3,4-O-isopropylidene-1-thio-β-D-galactopyranoside

: 364630-24-0
methyl 9-[3-O-(5,5-di-tert-butyloxycarbonylpentyl)-2-O-p-methoxybenzyl-4,6-O-benzylidene-α-D-galactopyranosyloxy]-nonanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: 100 percent / pyridine / 5 h

2.1: 64 percent / NaH / dimethylformamide / 2 h / 22 °C

3.1: 78 percent / aq. AcOH / 1.5 h / 60 °C

4.1: 62 percent / p-toluenesulfonic acid / acetonitrile / 22 °C

5.1: 59 percent / NaH / dimethylformamide / 22 °C

6.1: 82 percent / t-BuOK / 2-methyl-propan-2-ol; tetrahydrofuran; dimethylformamide / 50 - 60 °C

7.1: 2,6-di-tert-butyl-4-methylpyridine / toluene / 22 °C

7.2: 40 percent / dimethyl(methylthio)sulfonium triflate / toluene

With 2,6-di-tert-butyl-4-methylpyridine; potassium tert-butylate; sodium hydride; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; pyridine; N,N-dimethyl-formamide; toluene; acetonitrile; tert-butyl alcohol;
DOI:10.1016/S0968-0896(01)00015-3