antibiotic G 2N

Base Information

• Chemical Name: antibiotic G 2N
• CAS No.: 94129-85-8
• Molecular Formula: C₂₃H₁₆O₆
• Molecular Weight: 388.376
• Hs Code.: 2914690090
• Mol file: 94129-85-8.mol

Synonyms:G 2N; G 2N(pigment)

Chemical Property of antibiotic G 2N

Chemical Property:

• Vapor Pressure: 1.82E-22mmHg at 25°C
• Boiling Point: 737.1°Cat760mmHg
• Flash Point: 413.5°C
• PSA: 115.06000
• Density: 1.58g/cm³
• LogP: 3.35840

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of antibiotic G 2N

There total 21 articles about antibiotic G 2N which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

1,7,9,11-Tetramethoxy-3-methyl-8,13-dioxo-5,6,8,13-tetrahydro-benzo[a]naphthacene-2-carboxylic acid methyl ester (149913-04-2) → G-2N (94129-85-8)

Guidance literature:

With pyridine hydrochloride; at 160 ℃; for 6h;

Reference yield: 69.0%

G-2A (94129-75-6) → G-2N (94129-85-8)

Guidance literature:

DOI:10.1002/(sici)1099-0690(199911)1999:11<3099::aid-ejoc3099>3.0.co;2-2

Reference yield:

Trifluoro-methanesulfonic acid 4,5,7-trimethoxy-9,10-dioxo-3-vinyl-9,10-dihydro-anthracen-2-yl ester (149912-94-7) → G-2N (94129-85-8)

Guidance literature:

Multi-step reaction with 6 steps

1: 95 percent / Pd(CF₃COO)2, P(C₆H₅)3, i-Pr₂NH, CF₃COOAg / tetrahydrofuran / 90 °C

2: 77 percent / Zn, conc. aq. HCl, N-methylpyrrolidinone

3: 92 percent / H₂SO₄

4: 99 percent / Ag₂O

5: 44 percent / (Me₃Sn)2, (Ph₃P)4Pd / 168 h / 100 °C

6: 77 percent / Py*HCl / 6 h / 160 °C

With 1-methyl-pyrrolidin-2-one; hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium(II) trifluoroacetate; sulfuric acid; hexamethyldistannane; pyridine hydrochloride; silver trifluoroacetate; diisopropylamine; triphenylphosphine; silver(l) oxide; zinc; In tetrahydrofuran;

upstream raw materials:

1,7,9,11-Tetramethoxy-3-methyl-8,13-dioxo-5,6,8,13-tetrahydro-benzo[a]naphthacene-2-carboxylic acid methyl ester

1,3-bis(trimethylsiloxy)-1-methoxybuta-1,3-diene

G-2A

1-ethoxy-3,8-dihydroxy-6-methoxy-2-methyl-9,10-anthraquinone

Refernces

• 1、 Kraus, George A.,Zhao, Guohua. "Direct synthesis of G-2N". . p. 2770 - 2773. Retrieved 2007/10/03.