C₂HF₃O₂*C₁₄H₂₀FNO₂

Base Information

Chemical Name:C₂HF₃O₂*C₁₄H₂₀FNO₂
CAS No.:1352133-66-4
Molecular Formula:C₂HF₃O₂*C₁₄H₂₀FNO₂
Molecular Weight:367.341
Hs Code.:

C<sub>2</sub>HF<sub>3</sub>O<sub>2</sub>*C<sub>14</sub>H<sub>20</sub>FNO<sub>2</sub>

Synonyms:C₂HF₃O₂*C₁₄H₂₀FNO₂

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₂HF₃O₂*C₁₄H₂₀FNO₂

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Technology Process of C₂HF₃O₂*C₁₄H₂₀FNO₂

There total 7 articles about C₂HF₃O₂*C₁₄H₂₀FNO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1352133-86-8
methyl (2S,3S)-3-(dibenzylamino)-2-hydroxy-5-methylhexanoate

: 1352133-66-4
C₂HF₃O₂*C₁₄H₂₀FNO₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / 0 °C / Inert atmosphere

2.1: lithium hydroxide / ethanol; water / 1 h / 20 °C

2.2: 0 °C / Cooling with ice

3.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

4.1: triethylamine / methanol / 12 h / 20 °C

5.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

5.2: 12 h / 20 °C

6.1: dichloromethane / 1.5 h / 0 °C

With diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; caesium carbonate; triethylamine; lithium hydroxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100340

Reference yield:

: 118970-39-1
(2S,3S)-3-(dibenzylamino)-2-hydroxy-5-methylhexanenitrile

: 1352133-66-4
C₂HF₃O₂*C₁₄H₂₀FNO₂

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogenchloride / 12 h / 20 °C

2.1: diethylamino-sulfur trifluoride / dichloromethane / 3 h / 0 °C / Inert atmosphere

3.1: lithium hydroxide / ethanol; water / 1 h / 20 °C

3.2: 0 °C / Cooling with ice

4.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

5.1: triethylamine / methanol / 12 h / 20 °C

6.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

6.2: 12 h / 20 °C

7.1: dichloromethane / 1.5 h / 0 °C

With hydrogenchloride; diethylamino-sulfur trifluoride; palladium 10% on activated carbon; hydrogen; caesium carbonate; triethylamine; lithium hydroxide; In methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100340

Reference yield:

: (2S,3S)-3-Amino-2-fluoro-5-methyl-hexanoic acid

: 1352133-66-4
C₂HF₃O₂*C₁₄H₂₀FNO₂

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / methanol / 12 h / 20 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.17 h / 20 °C

2.2: 12 h / 20 °C

3.1: dichloromethane / 1.5 h / 0 °C

With caesium carbonate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.201100340