6-[2-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenyl]-hex-5-ynoic acid benzyl ester

Base Information

Chemical Name:6-[2-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenyl]-hex-5-ynoic acid benzyl ester
CAS No.:1027905-11-8
Molecular Formula:C₂₉H₂₉N₅O₃
Molecular Weight:495.581
Hs Code.:

6-[2-(2,4-diamino-5-methyl-pyrido[2,3-<i>d</i>]pyrimidin-6-ylmethyl)-4-methoxy-phenyl]-hex-5-ynoic acid benzyl ester

Synonyms:6-[2-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenyl]-hex-5-ynoic acid benzyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 6-[2-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenyl]-hex-5-ynoic acid benzyl ester

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 6-[2-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenyl]-hex-5-ynoic acid benzyl ester

There total 9 articles about 6-[2-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenyl]-hex-5-ynoic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 860771-48-8
6-(2-iodo-5-methoxy-benzyl)-5-methyl-pyrido[2,3-d]pyrimidine-2,4-diamine

: 499973-10-3
phenylmethyl hex-5-ynoate

: 1027905-11-8
6-[2-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenyl]-hex-5-ynoic acid benzyl ester

Guidance literature:: With triethylamine; triphenylphosphine; copper(I) bromide; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 80 ℃; for 120h;
DOI:10.1021/jm0581718

Reference yield:

: 860771-46-6
2,4-diamino-5-methyl-6-(3'-methoxybenzyl)pyrido[2,3-d]pyrimidine

: 1027905-11-8
6-[2-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenyl]-hex-5-ynoic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N-iodosuccinimide / trifluoroacetic acid / 20 °C

2: CuBr; Ph₃P; Et₃N / (Ph₃P)2PdCl₂ / dimethylformamide / 120 h / 80 °C

With N-iodo-succinimide; triethylamine; triphenylphosphine; copper(I) bromide; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; trifluoroacetic acid; 2: Sonogashira reaction;
DOI:10.1021/jm0581718

Reference yield:

: 860771-45-5
2,4-diamino-5-methyl-6-(3'-methoxybenzyl)-7-chloropyrido[2,3-d]pyrimidine

: 1027905-11-8
6-[2-(2,4-diamino-5-methyl-pyrido[2,3-d]pyrimidin-6-ylmethyl)-4-methoxy-phenyl]-hex-5-ynoic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium formate; Pd/C / 2-methoxy-ethanol / 4 h / Heating

2: N-iodosuccinimide / trifluoroacetic acid / 20 °C

3: CuBr; Ph₃P; Et₃N / (Ph₃P)2PdCl₂ / dimethylformamide / 120 h / 80 °C

With palladium on activated charcoal; N-iodo-succinimide; sodium formate; triethylamine; triphenylphosphine; copper(I) bromide; bis-triphenylphosphine-palladium(II) chloride; In 2-methoxy-ethanol; N,N-dimethyl-formamide; trifluoroacetic acid; 3: Sonogashira reaction;
DOI:10.1021/jm0581718