N-(2-bromo-4-trifluoromethoxyphenyl)-N-tert-butoxycarbonylphenylethynylamine

Base Information

Chemical Name:N-(2-bromo-4-trifluoromethoxyphenyl)-N-tert-butoxycarbonylphenylethynylamine
CAS No.:1440672-50-3
Molecular Formula:C₂₀H₁₇BrF₃NO₃
Molecular Weight:456.259
Hs Code.:

Synonyms:N-(2-bromo-4-trifluoromethoxyphenyl)-N-tert-butoxycarbonylphenylethynylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(2-bromo-4-trifluoromethoxyphenyl)-N-tert-butoxycarbonylphenylethynylamine

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Technology Process of N-(2-bromo-4-trifluoromethoxyphenyl)-N-tert-butoxycarbonylphenylethynylamine

There total 2 articles about N-(2-bromo-4-trifluoromethoxyphenyl)-N-tert-butoxycarbonylphenylethynylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1057720-35-0
tert-butyl N-[2-bromo-4-(trifluoromethoxy)phenyl]carbamate

: 932-87-6
1-Bromo-2-phenylacetylene

: 1440672-50-3
N-(2-bromo-4-trifluoromethoxyphenyl)-N-tert-butoxycarbonylphenylethynylamine

Guidance literature:: With potassium phosphate; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; In toluene; for 24h; Inert atmosphere; Reflux;
DOI:10.1021/ol4013298

Reference yield:

: 536-74-3
phenylacetylene

: 1440672-50-3
N-(2-bromo-4-trifluoromethoxyphenyl)-N-tert-butoxycarbonylphenylethynylamine

Guidance literature:: Multi-step reaction with 2 steps

1: N-Bromosuccinimide; silver nitrate / acetone / 20 °C / Inert atmosphere

2: potassium phosphate; copper(ll) sulfate pentahydrate; 1,10-Phenanthroline / toluene / 24 h / Inert atmosphere; Reflux

With potassium phosphate; N-Bromosuccinimide; 1,10-Phenanthroline; copper(ll) sulfate pentahydrate; silver nitrate; In acetone; toluene;
DOI:10.1021/ol4013298

Reference yield: 64.0%

: 1440672-50-3
N-(2-bromo-4-trifluoromethoxyphenyl)-N-tert-butoxycarbonylphenylethynylamine

: 1440673-57-3
N-tert-butoxycarbonyl-3-phenyl-5-trifluoromethoxyindole

Guidance literature:: N-(2-bromo-4-trifluoromethoxyphenyl)-N-tert-butoxycarbonylphenylethynylamine; With tert.-butyl lithium; In diethyl ether; pentane; at -78 ℃; Inert atmosphere;

With copper(I) cyanide di(lithium chloride); In tetrahydrofuran; diethyl ether; pentane; at -78 - 20 ℃; for 14h; Inert atmosphere;
DOI:10.1021/ol4013298