4-chloro-N-(2-chloro-4-methoxy-benzoyl)-benzenesulfonamide

Base Information

• Chemical Name: 4-chloro-N-(2-chloro-4-methoxy-benzoyl)-benzenesulfonamide
• CAS No.: 791618-64-9
• Molecular Formula: C₁₄H₁₁Cl₂NO₄S
• Molecular Weight: 360.218
• Mol file: 791618-64-9.mol

Synonyms:4-chloro-N-(2-chloro-4-methoxy-benzoyl)-benzenesulfonamide

Chemical Property of 4-chloro-N-(2-chloro-4-methoxy-benzoyl)-benzenesulfonamide

Chemical Property:

Purity/Quality:

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Technology Process of 4-chloro-N-(2-chloro-4-methoxy-benzoyl)-benzenesulfonamide

There total 2 articles about 4-chloro-N-(2-chloro-4-methoxy-benzoyl)-benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-Chlorobenzenesulfonamide (98-64-6) + 2-chloro-4-methoxybenzoic acid (21971-21-1) → 4-chloro-N-(2-chloro-4-methoxy-benzoyl)-benzenesulfonamide (791618-64-9)

Guidance literature:

With dmap; 1-(3-dimethylaminopropyl)-3-ethylenecarbodiimide*HCl; In dichloromethane; for 16h;

DOI:10.1021/jm030594r

Reference yield:

2-chloro-4-hydroxybenzoic acid (56363-84-9) → 4-chloro-N-(2-chloro-4-methoxy-benzoyl)-benzenesulfonamide (791618-64-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / K₂CO₃ / acetone / 6 h / Heating

2: 98 percent / 4-(dimethylamino)pyridine; 1-(3-dimethylaminopropyl)-3-ethylenecarbodiimide*HCl / CH₂Cl₂ / 16 h

With dmap; 1-(3-dimethylaminopropyl)-3-ethylenecarbodiimide*HCl; potassium carbonate; In dichloromethane; acetone;

DOI:10.1021/jm030594r

Reference yield: 90.0%

4-chloro-N-(2-chloro-4-methoxy-benzoyl)-benzenesulfonamide (791618-64-9) → 4-chloro-N-(2-chloro-4-hydroxy-benzoyl)-benzenesulfonamide

Guidance literature:

With boron tribromide; In dichloromethane; at -20 - 40 ℃; for 4h;

DOI:10.1021/jm030594r

upstream raw materials:

4-Chlorobenzenesulfonamide

2-chloro-4-methoxybenzoic acid

2-chloro-4-hydroxybenzoic acid