methyl 2-methyl-3-phenylimidazo[1,2-a]pyridine-6-carboxylate

Base Information

• Chemical Name: methyl 2-methyl-3-phenylimidazo[1,2-a]pyridine-6-carboxylate
• CAS No.: 1360881-88-4
• Molecular Formula: C₁₆H₁₄N₂O₂
• Molecular Weight: 266.299
• Mol file: 1360881-88-4.mol

Synonyms:methyl 2-methyl-3-phenylimidazo[1,2-a]pyridine-6-carboxylate

Chemical Property of methyl 2-methyl-3-phenylimidazo[1,2-a]pyridine-6-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-methyl-3-phenylimidazo[1,2-a]pyridine-6-carboxylate

There total 2 articles about methyl 2-methyl-3-phenylimidazo[1,2-a]pyridine-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

methyl 3-iodo-2-methylimidazo[1,2-a]pyridine-6-carboxylate (1360881-85-1) + phenylboronic acid (98-80-6) → methyl 2-methyl-3-phenylimidazo[1,2-a]pyridine-6-carboxylate (1360881-88-4)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; for 20h; Reflux;

Reference yield:

methyl 6-aminonicotinoate (36052-24-1) → methyl 2-methyl-3-phenylimidazo[1,2-a]pyridine-6-carboxylate (1360881-88-4)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 24 h / Reflux

2: iodine; pyridine / 4 h / 50 °C

3: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / 1,2-dimethoxyethane; water / 20 h / Reflux

With pyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; iodine; potassium carbonate; In 1,2-dimethoxyethane; ethanol; water;

Reference yield: 98.0%

methyl 2-methyl-3-phenylimidazo[1,2-a]pyridine-6-carboxylate (1360881-88-4) → 2-methyl-3-phenylimidazo[1,2-a]pyridine-6-carboxylic acid (1360881-89-5)

Guidance literature:

methyl 2-methyl-3-phenylimidazo[1,2-a]pyridine-6-carboxylate; With water; lithium hydroxide; In tetrahydrofuran; ethanol; for 12h;

With hydrogenchloride; In tetrahydrofuran; water;

upstream raw materials:

methyl 3-iodo-2-methylimidazo[1,2-a]pyridine-6-carboxylate

phenylboronic acid

methyl 6-aminonicotinoate

Downstream raw materials:

2-methyl-3-phenylimidazo[1,2-a]pyridine-6-carboxylic acid

tert-butyl 4-(2-methyl-3-phenylimidazo[1,2-a]pyridine-6-carbonyl)piperazine-1-carboxylate

(4-(cyclohexanecarbonyl)piperazin-1-yl)(2-methyl-3-phenyl imidazo[1,2-a]pyridin-6-yl)methanone