(S)-2-Amino-6-benzyloxy-3-hydroxy-hexanoic acid ((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-amide

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Chemical Name:(S)-2-Amino-6-benzyloxy-3-hydroxy-hexanoic acid ((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-amide
CAS No.:184005-56-9
Molecular Formula:C₂₅H₃₈N₂O₈
Molecular Weight:494.585
Hs Code.:

(S)-2-Amino-6-benzyloxy-3-hydroxy-hexanoic acid ((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-amide

Synonyms:(S)-2-Amino-6-benzyloxy-3-hydroxy-hexanoic acid ((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-amide

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Chemical Property of (S)-2-Amino-6-benzyloxy-3-hydroxy-hexanoic acid ((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-amide

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Technology Process of (S)-2-Amino-6-benzyloxy-3-hydroxy-hexanoic acid ((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-amide

There total 7 articles about (S)-2-Amino-6-benzyloxy-3-hydroxy-hexanoic acid ((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 184005-55-8
{(S)-5-Benzyloxy-2-hydroxy-1-[((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-carbamoyl]-pentyl}-carbamic acid tert-butyl ester

: 184005-56-9
(S)-2-Amino-6-benzyloxy-3-hydroxy-hexanoic acid ((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-amide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 23 ℃; for 2h;
DOI:10.1016/S0968-0896(96)00236-2

Reference yield:

: 70932-44-4
6-azido-1,2,3,4-di-O-isopropylidene-6-deoxy-α-L-galactopyranoside

: 184005-56-9
(S)-2-Amino-6-benzyloxy-3-hydroxy-hexanoic acid ((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / H₂ / Pd/C / methanol / 1824 Torr

2: N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide, hydroxybenzotriazole / dimethylformamide / -20 - 23 °C

3: 10percent aq. TFA / CH₂Cl₂

With hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 4064-06-6,27108-09-4,72361-04-7,99166-41-3,110319-61-4,148623-63-6,150199-47-6,70932-37-5
1,2:3,4-di-O-isopropylidene-α-L-galactopyranose

: 184005-56-9
(S)-2-Amino-6-benzyloxy-3-hydroxy-hexanoic acid ((3aS,5S,5aR,8aR,8bS)-2,2,7,7-tetramethyl-tetrahydro-bis[1,3]dioxolo[4,5-b;4',5'-d]pyran-5-ylmethyl)-amide

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / pyridine

2: 91 percent / NaN₃ / dimethylformamide / 115 °C

3: 100 percent / H₂ / Pd/C / methanol / 1824 Torr

4: N-ethyl-N'-(3-dimethylaminopropyl)carbodiimide, hydroxybenzotriazole / dimethylformamide / -20 - 23 °C

5: 10percent aq. TFA / CH₂Cl₂

With pyridine; sodium azide; hydrogen; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; trifluoroacetic acid; palladium on activated charcoal; In methanol; dichloromethane; N,N-dimethyl-formamide;