methyl 2-(4-((2-(1-ethoxyvinyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate

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Chemical Name:methyl 2-(4-((2-(1-ethoxyvinyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate
CAS No.:1621363-49-2
Molecular Formula:C₂₀H₂₂N₂O₄
Molecular Weight:354.406
Hs Code.:

Synonyms:methyl 2-(4-((2-(1-ethoxyvinyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate

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Chemical Property of methyl 2-(4-((2-(1-ethoxyvinyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate

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Technology Process of methyl 2-(4-((2-(1-ethoxyvinyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate

There total 4 articles about methyl 2-(4-((2-(1-ethoxyvinyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 1621363-01-6
2-(4-(2-chloro-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yloxy)phenyl)acetic acid methyl ester

: 97674-02-7
tributyl(1-ethoxyvinyl)stannane

: 1621363-49-2
methyl 2-(4-((2-(1-ethoxyvinyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate

Guidance literature:: With bis(tri-t-butylphosphine)palladium⁽⁰⁾; cesium fluoride; In 1,4-dioxane; at 120 ℃; for 2h;

Reference yield:

: 5466-43-3
2,4-dichloro-6,7-dihydro-5H-cyclopentapyrimidine

: 1621363-49-2
methyl 2-(4-((2-(1-ethoxyvinyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 2 h / Reflux

2: cesium fluoride; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 120 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; 1,8-diazabicyclo[5.4.0]undec-7-ene; cesium fluoride; In 1,4-dioxane;

Reference yield:

: 5466-00-2
1,5,6,7-tetrahydro-cyclopentapyrimidine-2,4-dione

: 1621363-49-2
methyl 2-(4-((2-(1-ethoxyvinyl)-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl)oxy)phenyl)acetate

Guidance literature:: Multi-step reaction with 3 steps

1: trichlorophosphate; sodium hydrogencarbonate / 24 h / 85 - 100 °C / Cooling with ice

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 2 h / Reflux

3: cesium fluoride; bis(tri-t-butylphosphine)palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 120 °C

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; sodium hydrogencarbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; cesium fluoride; trichlorophosphate; In 1,4-dioxane;