Technology Process of C18H29F3N4O5
There total 5 articles about C18H29F3N4O5 which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethanol; water; ethyl acetate;
under 2327.17 Torr;
DOI:10.1021/jo9815204
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 81 percent / aq. HCl / dioxane / 1 h
2: 37 percent / p-toluenesulfonic acid monohydrate / toluene / 3 h / Heating
3: 99 percent / H2 / Pd/C / ethyl acetate; ethanol; H2O / 2327.17 Torr
With
hydrogenchloride; hydrogen; toluene-4-sulfonic acid;
palladium on activated charcoal;
In
1,4-dioxane; ethanol; water; ethyl acetate; toluene;
1: Hydrolysis / 2: Condensation / 3: Hydrogenolysis;
DOI:10.1021/jo9815204
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 36.0 g / oxalyl chloride; DMSO; triethylamine / CH2Cl2 / 4.5 h / -78 - 0 °C
2: 37 percent / p-toluenesulfonic acid monohydrate / toluene / 3 h / Heating
3: 99 percent / H2 / Pd/C / ethyl acetate; ethanol; H2O / 2327.17 Torr
With
oxalyl dichloride; hydrogen; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
palladium on activated charcoal;
In
ethanol; dichloromethane; water; ethyl acetate; toluene;
1: Swern oxidation / 2: Condensation / 3: Hydrogenolysis;
DOI:10.1021/jo9815204