HNC₆H₄CH₃C(C₆H₅)CHN₂C₃H(CH₃)2

Base Information

• Chemical Name: HNC₆H₄CH₃C(C₆H₅)CHN₂C₃H(CH₃)2
• CAS No.: 1148119-99-6
• Molecular Formula: C₂₀H₂₁N₃
• Molecular Weight: 303.407
• Mol file: 1148119-99-6.mol

Synonyms:HNC₆H₄CH₃C(C₆H₅)CHN₂C₃H(CH₃)2

Chemical Property of HNC₆H₄CH₃C(C₆H₅)CHN₂C₃H(CH₃)2

Chemical Property:

Purity/Quality:

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Technology Process of HNC₆H₄CH₃C(C₆H₅)CHN₂C₃H(CH₃)2

There total 1 articles about HNC₆H₄CH₃C(C₆H₅)CHN₂C₃H(CH₃)2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-phenylethan-1-one (87581-58-6) + o-toluidine (95-53-4) → HNC6H4CH3C(C6H5)CHN2C3H(CH3)2 (1148119-99-6)

Guidance literature:

With formic acid; In toluene; for 12h; Inert atmosphere; Reflux; Molecular sieve;

DOI:10.1039/b811094h

Reference yield: 70.0%

HNC6H4CH3C(C6H5)CHN2C3H(CH3)2 (1148119-99-6) → C20H20N3(1-)*Li(1+)

Guidance literature:

With n-butyllithium; In hexane; toluene; at -80 - 20 ℃; Inert atmosphere;

DOI:10.1039/b811094h

Reference yield: 70.0%

HNC6H4CH3C(C6H5)CHN2C3H(CH3)2 (1148119-99-6) + triethylaluminum (97-93-8) → [Al(C2H5)2(NC6H4(CH3)C(C6H5)CHN2C3H(CH3)2)] (1148120-17-5) + [Al(C2H5)2(NC6H4(CH3)C(C6H5)C2H5CH2N2C3H(CH3)2)] (1148120-19-7)

Guidance literature:

In hexane; toluene; under N2, Schlenk technique; soln. of AlEt3 in hexane added to soln. of pyrazole deriv. in toluene at ca. -80°C under stirring, mixt. warmed to room temp. and stirred overnight; soln. evapd. under vac., residue dissolved in hexane, filtered, filtrateconcd., crystals sepd., some crystals of triethyl compd. obtained from mother liquor after 2 days; elem. anal.;

DOI:10.1039/b811094h

upstream raw materials:

2-(3,5-dimethyl-1H-pyrazol-1-yl)-1-phenylethan-1-one

o-toluidine

Downstream raw materials:

[Al(CH₃)2(NC₆H₄CH₃C(C₆H₅)CHN₂C₃H(CH₃)2)]

[Al(C₂H₅)2(NC₆H₄(CH₃)C(C₆H₅)CHN₂C₃H(CH₃)2)]

[Al(C₂H₅)2(NC₆H₄(CH₃)C(C₆H₅)C₂H₅CH₂N₂C₃H(CH₃)2)]