1-<2-Deoxy-3,5-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl>-6-nitrobenzimidazole

Base Information

Chemical Name:1-<2-Deoxy-3,5-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl>-6-nitrobenzimidazole
CAS No.:127553-32-6
Molecular Formula:C₂₈H₂₅N₃O₇
Molecular Weight:515.522
Hs Code.:

Synonyms:1-<2-Deoxy-3,5-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl>-6-nitrobenzimidazole

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Chemical Property of 1-<2-Deoxy-3,5-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl>-6-nitrobenzimidazole

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Technology Process of 1-<2-Deoxy-3,5-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl>-6-nitrobenzimidazole

There total 1 articles about 1-<2-Deoxy-3,5-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl>-6-nitrobenzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 4330-21-6
2-deoxy-3,5-di-O-p-toluoyl-α-D-erythro-pentofuranosyl chloride

: 94-52-0
5-nitrobenzimidazole

: 127553-33-7
1-<2-Deoxy-3,5-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl>-5-nitrobenzimidazole

: 127553-32-6
1-<2-Deoxy-3,5-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl>-6-nitrobenzimidazole

Guidance literature:: With potassium hydroxide; TDA-1; 1.) CH₃CN, room temp., 30 min, 2.) 2 h;
DOI:10.1055/s-1989-27429

Reference yield: 100.0%

: 127553-32-6
1-<2-Deoxy-3,5-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl>-6-nitrobenzimidazole

: 760948-81-0
C₂₈H₂₇N₃O₅

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran;
DOI:10.1016/j.tetlet.2004.06.095

Reference yield:

: 127553-32-6
1-<2-Deoxy-3,5-bis-O-(4-methylbenzoyl)-β-D-erythro-pentofuranosyl>-6-nitrobenzimidazole

: N-(3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-3H-benzoimidazol-5-yl)-3-[2,4-dioxo-1-(2-trimethylsilanyl-ethoxymethyl)-1,2,3,4-tetrahydro-pyrimidin-5-yl]-propionamide

Guidance literature:: Multi-step reaction with 6 steps

1: 100 percent / H₂ / Pd/C / tetrahydrofuran

2: 84 percent / Et₃N / CH₂Cl₂

3: 95 percent / PPh₃; Et₃N / Pd(OAc)2 / dioxane / Heating

4: 93 percent / aq. NH₃ / ethanol

5: 92 percent / Pd/C / acetic acid; tetrahydrofuran

6: Et₃N / dimethylformamide

With ammonium hydroxide; hydrogen; triethylamine; triphenylphosphine; palladium diacetate; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; acetic acid; N,N-dimethyl-formamide;
DOI:10.1016/j.tetlet.2004.06.095