((R)-6-chlorosulfonyl-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester

Base Information

Chemical Name:((R)-6-chlorosulfonyl-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester
CAS No.:1000300-19-5
Molecular Formula:C₁₉H₂₀ClNO₄S
Molecular Weight:393.891
Hs Code.:

Synonyms:((R)-6-chlorosulfonyl-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester

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Chemical Property of ((R)-6-chlorosulfonyl-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester

Chemical Property:

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Technology Process of ((R)-6-chlorosulfonyl-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester

There total 10 articles about ((R)-6-chlorosulfonyl-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: ((R)-6-benzylsulfanyl-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester

: 1000300-19-5
((R)-6-chlorosulfonyl-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester

Guidance literature:: With N-chloro-succinimide; acetic acid; In water; at 23 ℃; for 2h;

Reference yield:

: 340825-13-0
6-iodo-3,4-dihydro-2H-naphthalen-1-one

: 1000300-19-5
((R)-6-chlorosulfonyl-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: borane N,N-diethylaniline complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / toluene / 3 h / 30 °C

1.2: 0.25 h / 20 °C

2.1: di-isopropyl azodicarboxylate; trimethylphosphane / toluene / 0.5 h / -50 °C

3.1: methanol; sodium hydroxide; water / 20 h / Heating / reflux

3.2: 2 h / Heating / reflux

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 23 °C

5.1: sodium azide / water; acetone / 0.5 h / 0 °C

5.2: 0.67 h / Heating / reflux

6.1: sodium carbonate / water; toluene / 2 h / 23 °C

7.1: N-ethyl-N,N-diisopropylamine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 50 °C

8.1: N-chloro-succinimide; acetic acid / water / 2 h / 23 °C

With methanol; sodium hydroxide; N-chloro-succinimide; borane N,N-diethylaniline complex; sodium azide; oxalyl dichloride; di-isopropyl azodicarboxylate; water; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; trimethylphosphane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; dichloromethane; water; acetone; toluene;

Reference yield:

: (R)-C-(6-iodo-1,2,3,4-tetrahydro-naphthalen-1-yl)-methylamine hydrochloride

: 1000300-19-5
((R)-6-chlorosulfonyl-1,2,3,4-tetrahydro-naphthalen-1-ylmethyl)-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: sodium carbonate / water; toluene / 2 h / 23 °C

2: N-ethyl-N,N-diisopropylamine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 1 h / 50 °C

3: N-chloro-succinimide; acetic acid / water / 2 h / 23 °C

With N-chloro-succinimide; sodium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; water; toluene;