(3S)-t-butyldimethylsilyloxy-(2R)-(t-butyloxycarbonyl)amino-4-chloro-1-phenylthiobutane

Base Information

Chemical Name:(3S)-t-butyldimethylsilyloxy-(2R)-(t-butyloxycarbonyl)amino-4-chloro-1-phenylthiobutane
CAS No.:357604-39-8
Molecular Formula:C₂₁H₃₆ClNO₃SSi
Molecular Weight:446.126
Hs Code.:

Synonyms:(3S)-t-butyldimethylsilyloxy-(2R)-(t-butyloxycarbonyl)amino-4-chloro-1-phenylthiobutane

Suppliers and Price of (3S)-t-butyldimethylsilyloxy-(2R)-(t-butyloxycarbonyl)amino-4-chloro-1-phenylthiobutane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S)-t-butyldimethylsilyloxy-(2R)-(t-butyloxycarbonyl)amino-4-chloro-1-phenylthiobutane

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (3S)-t-butyldimethylsilyloxy-(2R)-(t-butyloxycarbonyl)amino-4-chloro-1-phenylthiobutane

There total 3 articles about (3S)-t-butyldimethylsilyloxy-(2R)-(t-butyloxycarbonyl)amino-4-chloro-1-phenylthiobutane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 108-98-5
thiophenol

: 326480-01-7
N-t-butyloxycarbonyl-2(S)-(1(S)-t-butyldimethylsilyloxy-2-chloroethyl)aziridine

: 357604-39-8
(3S)-t-butyldimethylsilyloxy-(2R)-(t-butyloxycarbonyl)amino-4-chloro-1-phenylthiobutane

Guidance literature:: With triethylamine; In methanol; at 20 ℃; for 18h;
DOI:10.1021/ol016147s

Reference yield:

: 326479-99-6
2(R)-((tert-butyloxycarbonyl)amino)-1,4-dichloro-3(S)-hydroxybutane

: 357604-39-8
(3S)-t-butyldimethylsilyloxy-(2R)-(t-butyloxycarbonyl)amino-4-chloro-1-phenylthiobutane

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / imidazole; DMAP / dimethylformamide / 12 h / 50 °C

2: 100 percent / NaH / tetrahydrofuran / 5 h / 0 °C

3: 82 percent / Et₃N / methanol / 18 h / 20 °C

With 1H-imidazole; dmap; sodium hydride; triethylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1021/ol016147s

Reference yield:

: 326480-00-6
2(S)-t-butyldimethylsilyloxy-3(R)-(t-butyloxycarbonyl)amino-1,4-dichlorobutane

: 357604-39-8
(3S)-t-butyldimethylsilyloxy-(2R)-(t-butyloxycarbonyl)amino-4-chloro-1-phenylthiobutane

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / NaH / tetrahydrofuran / 5 h / 0 °C

2: 82 percent / Et₃N / methanol / 18 h / 20 °C

With sodium hydride; triethylamine; In tetrahydrofuran; methanol;
DOI:10.1021/ol016147s