N₁-(9-fluorenylmethoxycarbonylthiourea)-N₂,N₃-bis[2-(4-nitrophenyl)ethoxycarbonyl]-N₄-(4-monomethoxytrityl)spermine

Base Information

• Chemical Name: N₁-(9-fluorenylmethoxycarbonylthiourea)-N₂,N₃-bis[2-(4-nitrophenyl)ethoxycarbonyl]-N₄-(4-monomethoxytrityl)spermine
• CAS No.: 1292221-12-5
• Molecular Formula: C₆₄H₆₇N₇O₁₁S
• Molecular Weight: 1142.34

Synonyms:N₁-(9-fluorenylmethoxycarbonylthiourea)-N₂,N₃-bis[2-(4-nitrophenyl)ethoxycarbonyl]-N₄-(4-monomethoxytrityl)spermine

Chemical Property of N₁-(9-fluorenylmethoxycarbonylthiourea)-N₂,N₃-bis[2-(4-nitrophenyl)ethoxycarbonyl]-N₄-(4-monomethoxytrityl)spermine

Chemical Property:

Purity/Quality:

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Technology Process of N₁-(9-fluorenylmethoxycarbonylthiourea)-N₂,N₃-bis[2-(4-nitrophenyl)ethoxycarbonyl]-N₄-(4-monomethoxytrityl)spermine

There total 10 articles about N₁-(9-fluorenylmethoxycarbonylthiourea)-N₂,N₃-bis[2-(4-nitrophenyl)ethoxycarbonyl]-N₄-(4-monomethoxytrityl)spermine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

N1-(4-monomethoxytrityl)-N2,N3-bis[2-(4-nitrophenyl)ethoxycarbonyl]spermine (1292221-11-4) + 9-fluorenylmethoxycarbonyl isothiocyanate (199915-38-3) → N1-(9-fluorenylmethoxycarbonylthiourea)-N2,N3-bis[2-(4-nitrophenyl)ethoxycarbonyl]-N4-(4-monomethoxytrityl)spermine (1292221-12-5)

Guidance literature:

In dichloromethane; at 0 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2011.01.061

Reference yield:

C28H38F12N4O8 → N1-(9-fluorenylmethoxycarbonylthiourea)-N2,N3-bis[2-(4-nitrophenyl)ethoxycarbonyl]-N4-(4-monomethoxytrityl)spermine (1292221-12-5)

Guidance literature:

Multi-step reaction with 6 steps

1.1: methanol / 1 h / 4 °C

2.1: water; sodium hydroxide / methanol

3.1: dmap / dichloromethane / 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2.08 h / 0 - 20 °C

4.2: 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0.92 h / 20 °C

6.1: dichloromethane / 0 °C / Inert atmosphere

With methanol; dmap; water; trifluoroacetic acid; sodium hydroxide; In methanol; dichloromethane;

DOI:10.1016/j.bmc.2011.01.061

Reference yield:

N1,N4-bis(tert-butoxycarbonyl)-N2,N3-bis[2-(4-nitrophenyl)ethoxycarbonyl]spermine (1292221-09-0) → N1-(9-fluorenylmethoxycarbonylthiourea)-N2,N3-bis[2-(4-nitrophenyl)ethoxycarbonyl]-N4-(4-monomethoxytrityl)spermine (1292221-12-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 2.08 h / 0 - 20 °C

1.2: 20 °C

2.1: trifluoroacetic acid / dichloromethane / 0.92 h / 20 °C

3.1: dichloromethane / 0 °C / Inert atmosphere

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.bmc.2011.01.061

upstream raw materials:

4-nitrophenethyl 4-nitrophenyl carbonate

N₁,N₄-bis(tert-butoxycarbonyl)-N₂,N₃-bis[2-(4-nitrophenyl)ethoxycarbonyl]spermine

N₁,N₄-bis(4-monomethoxytrityl)-N₂,N₃-bis[2-(4-nitrophenyl)ethoxycarbonyl]spermine

N₁-(4-monomethoxytrityl)-N₂,N₃-bis[2-(4-nitrophenyl)ethoxycarbonyl]spermine

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