2-Amino-N-hydroxybenzamide

Base Information

• Chemical Name: 2-Amino-N-hydroxybenzamide
• CAS No.: 5623-04-1
• Deprecated CAS: 2208-42-6
• Molecular Formula: C7H8 N2 O2
• Molecular Weight: 152.153
• European Community (EC) Number: 227-051-3
• NSC Number: 111686
• UNII: IOQ2I7HZ9C
• DSSTox Substance ID: DTXSID3063964
• Nikkaji Number: J225.059D
• Wikidata: Q81991130
• ChEMBL ID: CHEMBL3229642
• Mol file: 5623-04-1.mol

Synonyms:2-aminobenzhydroxamic acid;anthranilic hydroxamic acid

Chemical Property of 2-Amino-N-hydroxybenzamide

Chemical Property:

• Melting Point: 141-143°
• PKA: 8.82±0.40(Predicted)
• PSA: 75.35000
• Density: 1.345g/cm³
• LogP: 1.35990
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 152.058577502
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-N-hydroxybenzenecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)C(=O)NO)N

Technology Process of 2-Amino-N-hydroxybenzamide

There total 10 articles about 2-Amino-N-hydroxybenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-amino-N-(benzyloxy)benzamide (4797-75-5) → anthranilic hydroxamic acid (5623-04-1)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; for 2.5h;

DOI:10.1021/ol017036w

Reference yield: 99.0%

C14H12N2O4 (1138453-55-0) → anthranilic hydroxamic acid (5623-04-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol;

DOI:10.1021/ol900210h

Reference yield: 85.8%

isatoic anhydride (118-48-9) → anthranilic hydroxamic acid (5623-04-1)

Guidance literature:

With hydroxylamine hydrochloride; sodium carbonate; In water; at 20 ℃;

DOI:10.1002/ejoc.200801179

upstream raw materials:

2-carbomethoxyaniline

2-amino-N-(benzyloxy)benzamide

anthranilic acid

isatoic anhydride

Downstream raw materials:

1,3-dihydro-2H-benzimidazol-2-one

2-furan-2-yl-3-hydroxy-2,3-dihydro-1H-quinazolin-4-one

o-Amino-benzoyl-aminoxy-essigsaeureethylester

3-hydroxy-2-(2-hydroxyphenyl)-2,3-dihydroquinazolin-4(1H)-one

Refernces

• 1、 Chaiyaveij, Duangduan,Batsanov, Andrei S.,Fox, Mark A.,Marder, Todd B.,Whiting, Andrew. "An Experimental and Computational Approach to Understanding the Reactions of Acyl Nitroso Compounds in [4 + 2] Cycloadditions". . p. 9518 - 9534. Retrieved 2015/10/12.
• 2、 Tardibono Jr., Lawrence P.,Miller, Marvin J.. "Synthesis and anticancer activity of new hydroxamic acid containing 1,4-benzodiazepines". scheme or table. p. 1575 - 1578. Retrieved 2009/09/06.